Results 151 to 160 of about 161,071 (201)

Interleukin-1 receptor antagonist: effectiveness against interleokin-1 fever

Canadian Journal of Physiology and Pharmacology, 1992
Conscious cats were used to examine the effectiveness of the interleukin-1 receptor antagonist against the fever induced by interleukin-1 and endotoxin. Although inactive by itself, the antagonist (three 1-μg bolus injections at 10-min intervals), injected into the third ventricle, attenuated the febrile response to a subsequent ...
COCEANI, Flavio, LEES J, REDFORD J, BISHAI I.   +3 more
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Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Biochemical and Biophysical Research Communications, 1997
Interleukin-1 (IL-1) has been implicated in chronic and acute cerebral neuropathologies. IL-1 receptor antagonist (IL-1ra), a naturally occurring protein that binds to IL-1 receptors without inducing signal transduction, blocks several actions of IL-1. IL-1ra acts at the local level and it also circulates in the bloodstream.
Loddick, Sarah A., Wong, Ma Li, Bongiorno, Peter B., Gold, Philip W., Licinio, Julio, Rothwell, Nancy J.   +5 more
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Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

International Reviews of Immunology, 1998
IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with other cytokines or small mediator molecules. Although some lymphocyte and colony stimulating growth factors may be therapeutically useful, IL-1 is a ...
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Interleukin-1 Receptor Antagonist Expression in Sarcoidosis

American Review of Respiratory Disease, 1993
Sarcoidosis is a systemic granulomatous disease with a marked propensity for involvement of the pulmonary parenchyma and thoracic lymphatic system. This granulomatous process is characterized by aggregations of mononuclear cells, multinucleated giant cells, and variable degrees of fibrosis.
M W, Rolfe, T J, Standiford, S L, Kunkel, M D, Burdick, A R, Gilbert, J P, Lynch, R M, Strieter   +6 more
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INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology

Annual Review of Immunology, 1998
▪ Abstract  The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18-kDa form ...
W P, Arend, M, Malyak, C J, Guthridge, C, Gabay   +3 more
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Interleukin-1 Receptor Antagonist

1993
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a member of the IL-1 family by three criteria: amino acid sequence homology of 26 to 30% to IL-1 beta and 19% to IL-1 alpha; similarities in gene structure; and common gene localization to human chromosome 2q14.
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Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991
The recent purification and characterization of an interleukin 1-receptor antagonist (IL-1ra) has provided an additional means of elucidating the mechanisms involved in the responses initiated by IL-1. Central administration of IL-1 to rabbits results in a characteristic febrile response and in increased non-rapid-eye-movement sleep (NREMS).
M R, Opp, J M, Krueger
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Interleukin‐1 and interleukin‐1 receptor antagonist in inflammatory bowel disease.

Alimentary Pharmacology & Therapeutics, 1996
Ulcerative colitis (UC) and Crohn's disease (CD) are immunologically mediated disorders characterized by a chronic, relapsing inflammatory response. Elevation of several cytokines, with important immunoregulatory and proinflammatory activities have been demonstrated during active inflammatory bowel disease (IBD).
F, Cominelli, T T, Pizarro
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Interleukin-1 receptor antagonist

2000
Interleukin-1 (IL-1) is a proinflammatory cytokine produced by a wide variety of cell types with an equally pleiotropic range of activities including the induction of fever, hypotension, adhesion molecule expression, neutrophilia, cartilage destruc­tion, prostanoid production, and induction of the expression of a number of other cytokines. Two forms of
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Intracellular Interleukin-1 Receptor Antagonist in Osteoarthritis Chondrocytes

Clinical Orthopaedics and Related Research, 2003
The objective of the current study was to determine whether the balance of interleukin-1 and intracellular interleukin-1 receptor antagonist in chondrocytes in osteoarthritic human joints favors agonist action. Chondrocytes were isolated from cartilage specimens taken at the time of joint arthroplasty.
Minako, Murata, Carol, Trahan, Junichi, Hirahashi, Henry J, Mankin, Christine A, Towle   +4 more
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