Results 161 to 170 of about 161,071 (201)

lnterleukin-1 Receptor Antagonist

Critical Reviews™ in Immunology, 1995
The interleukin-1 receptor antagonist (IL-1ra) is unusual in that it is the only known naturally occurring, cytokine receptor antagonist with no apparent agonist function. Over the last 5 years, since the cloning of the IL-1ra cDNA sequence, there has been intensive research on the genetics, regulation, and potential therapeutic value of this protein ...
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Febrile Seizures: Interleukin 1β and Interleukin-1 Receptor Antagonist Polymorphisms

Pediatric Neurology, 2009
In order to investigate the association between IL-1beta -511 C-->T and IL-1 receptor antagonist intron 2 variable tandem repeat polymorphisms, and febrile seizures in children, 90 children (mean age, 19.7 +/- 11.2 months) diagnosed with febrile seizure and 106 healthy controls (mean age, 14.2 +/- 3.6 months) with no seizure or neurologic events were ...
Serdaroglu G., Alpman A., Tosun A., Pehlivan S., Özkınay F., Tekgül H., Gökben S.   +6 more
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Circulating interleukin-1 receptor antagonist levels in neonates

European Journal of Pediatrics, 1996
Circulating interleukin-1 receptor antagonist (IL-1 Ra) levels have been shown to reflect disease activity in certain conditions in adults. We determined circulating IL-1Ra references values for healthy neonates (healthy preterms and term infants with mild disease only) on days 2 (n = 17) and 4 of life (n = 23).
R, Geiger, H, Ellemunter, F M, Fink, M, Falk, H, Tilg   +4 more
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Interleukin‐1 receptor antagonist in the fetomaternal compartment

Acta Paediatrica, 1995
Interleukin‐1 (IL‐1) is a major mediator in infections and inflammation. Interleukin‐1 receptor antagonist (IL‐1ra) opposes the actions of IL‐1. IL‐1ra is present in exceptionally high concentrations in third trimester amniotic fluid. We studied IL‐1ra in amniotic fluid, fetal serum and newborn urine.
K, Bry, K, Teramo, U, Lappalainen, F, Waffarn, M, Hallman   +4 more
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Interleukin-1 and Interleukin-1 Receptor Antagonist in Systemic Lupus Erythematosus

Immunological Investigations, 1997
Interleukin-1 (IL-1) is thought to play an important role in the immunopathology of systemic lupus erythematosus (SLE). IL-1 receptor antagonist (IL-1ra) exhibits a dose-responsive inhibition of IL-1 effects, and Fcr receptors play a key role in IL-1ra production.
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IL1HY1: A Novel Interleukin-1 Receptor Antagonist Gene

Biochemical and Biophysical Research Communications, 1999
Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide variety of physiological and cellular events. We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%.
J J, Mulero, A M, Pace, S T, Nelken, D B, Loeb, T R, Correa, R, Drmanac, J E, Ford   +6 more
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Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis

Arthritis & Rheumatism, 1994
AbstractObjective. To quantify interleukin‐1 receptor antagonist (IL‐1ra) and IL‐1 production and gene expression by rheumatoid arthritis (RA) synovial tissue (ST) cells.Methods. IL‐1α, IL‐1β, and IL‐1ra protein levels were measured by enzyme‐linked immunosorbent assay in fresh and cultured ST cells, purified synovial macrophages, and fibroblast‐like ...
G S, Firestein, D L, Boyle, C, Yu, M M, Paine, T D, Whisenand, N J, Zvaifler, W P, Arend   +6 more
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Expression of interleukin-1 and interleukin-1 receptor antagonists in endometrial cancer

Gynecologic Oncology, 1991
The cytokine interleukin-1 (IL-1) can inhibit growth of breast cancer cells in culture and promote cellular differentiation in synergism with other growth factors. A secreted IL-1 receptor antagonist (sIL-1ra) has been described and an intracellular version (icIL-1ra) has been cloned; both antagonists block IL-1-dependent responses.
L, Van Le, S, Haskill, G J, Jaffe, W C, Fowler   +3 more
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Interleukin-1 Family Expression in Human Breast Cancer: Interleukin-1 Receptor Antagonist

Cancer Investigation, 2000
We hypothesize that interleukin-1 alpha, beta, and receptor antagonist (IL-1 alpha, IL-1 beta, and IL-1 ra, respectively) are present and tumor cell associated in human breast cancer (HBC). We believe the levels of these cytokines in breast tumor homogenates relate to other known prognosticators of patient survival (i.e., estrogen receptor [ER] status).
L J, Miller, S H, Kurtzman, K, Anderson, Y, Wang, M, Stankus, M, Renna, R, Lindquist, G, Barrows, D L, Kreutzer   +8 more
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[Interleukin 1 receptor antagonists].

Pediatrie, 1992
Interleukin 1 (IL-1) is a polypeptide cytokine produced by various cell types that mediates a broad range of biological activities and possesses a wide spectrum of immunologic and non immunologic properties. Interest has recently focussed on the role of IL-1 as an inflammatory mediator in chronic and acute diseases.
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