Results 291 to 300 of about 2,108,740 (316)

Interleukin-33 in health and disease

Nature Reviews Immunology, 2016
Interleukin-33 (IL-33) - a member of the IL-1 family - was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (Treg) cells, TH1 cells, CD8+ T cells and natural killer (NK ...
F. Liew, J. Girard, H. Turnquist
semanticscholar   +3 more sources

Interleukin-33 in atopic dermatitis.

Journal of Dermatological Science, 2019
Atopic dermatitis (AD) is characterized by pruritus, barrier disruption, and inflammationincluding type 2 cytokine production. Interleukin-33 (IL-33) is an inflammatory cytokine that is over-expressed in the keratinocytes of patients with AD.
Yasutomo Imai
semanticscholar   +3 more sources

Interleukin-33 and oxidative stress in epilepsy patients.

Epilepsy Research, 2021
İnflammation and oxidative stress plays an important role in the etiology of epilepsy. Interleukin-33 (IL-33), a new member of the cytokine family associated with interleukin-1 (IL-1), has been found to play a role in pathogenesis of central nervous system diseases and cause the production of proinflammatory cytokines and oxidative stress molecules ...
Ozlem Ethemoglu, M. Çalık, I. Koyuncu, K. Ethemoğlu, Adalet Göçmen, A. Güzelçi̇çek, Dursun Cadirci   +6 more
semanticscholar   +3 more sources

Interleukin 33 mediates hepatocyte autophagy and innate immune response in the early phase of acetaminophen-induced acute liver injury.

Toxicology, 2021
Despite interleukin 33 (IL-33) functions as an "alarmin" released from hepatic dead cells in response to tissue damages, the interrelationship between IL-33-mediated hepatocyte autophagy and innate immune response in the acetaminophen (APAP)-induced ...
Zengbin Wang, Linqing Wu, B. Pan, Yizhong Chen, Tao Zhang, N. Tang   +5 more
semanticscholar   +1 more source

Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke.

Experimental Neurology, 2020
Interleukin-33 (IL-33) is known to activate the regulatory T lymphocytes (Tregs), which are negatively correlated with brain damage after ischemic stroke.
Xin-jing Liu, Ruiyao Hu, L. Pei, Pan Si, Chunhui Wang, X. Tian, Xiao Wang, Han Liu, Beng Wang, Z. Xia, Yuming Xu, B. Song   +11 more
semanticscholar   +1 more source

Interleukin-33: increasing role in dermatological conditions

Archives of Dermatological Research, 2016
Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor.
Balato, Anna, Raimondo, Annunziata, Balato, Nicola, Ayala, Fabio, LEMBO, Serena   +4 more
openaire   +5 more sources

Role of interleukin 33 in human immunopathology

Annals of the Rheumatic Diseases, 2010
Interleukin 33 (IL33) is a recently described member of the IL1 superfamily of cytokines. Originally defined on the basis of T-cell subset differentiation, IL33 is now recognised to mediate a wider role in regulating components of the innate immune response also, particularly via mast cell activation.
G E J, Murphy, D, Xu, F Y, Liew, I B, McInnes   +3 more
openaire   +2 more sources

Interleukin‐33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin‐like growth factor‐binding protein 3

Journal of Cellular Physiology, 2020
Prolonged endoplasmic reticulum (ER) stress is the key driving force behind diabetic cardiomyopathy (DCM). Autophagy is extensively implicated in adaptive mechanisms for cell survival. Interleukin‐33 (IL‐33) is known to be a potent cardiac protector, but
Maoxiong Wu, Shaohua Wang, Yong Xie, Zhi-Teng Chen, Q. Guo, W. Yuan, Chang Guan, Chengzhang Xu, Yu-na Huang, Jing-Feng Wang, Hai-Feng Zhang, Yangxin Chen   +11 more
semanticscholar   +1 more source

Interleukin-33 and Atherosclerosis

2011
Interleukin (IL)-33 (also known as IL-1 F11) is a newly identified member of the IL-1 cytokine family with close amino acid sequence homology to IL-18 [1]. The human and mouse sequences for IL-33 have been mapped to chromosomes 9 (9p24.1) and 19 (19qc1), encoding proteins of 270 and 266 amino acids respectively.
Foo Y. Liew, Ashley M. Miller
openaire   +1 more source

Tranilast inhibits interleukin-33 production by macrophages

European Journal of Pharmacology, 2018
Tranilast is an anti-allergy medication that inhibits the release of chemical mediators such as histamine. However, the mechanisms underlying its anti-allergy effects are not fully understood. Interleukin (IL)-33, a novel member of the IL-1 cytokine family, promotes T helper type 2 immune responses and plays a pathogenic role in allergic disorders.
Sachiko, Hiraide, Yoshiki, Yanagawa, Kenji, Iizuka   +2 more
openaire   +2 more sources