Results 171 to 180 of about 604,134 (278)

Interleukin-1β-Induced Inflammatory Signaling and Myelin-Related Alterations in Oligodendroglia and Schwann Cells in Multiple Sclerosis: Modulatory Effects of Ibuprofen and Flurbiprofen. [PDF]

Curr Issues Mol Biol
Narasimhappagari J, Liu L, Griffin WST.
europepmc   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Hyperacute Interleukin-1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion. [PDF]

Ann Neurol
Münsterberg J, Brekenfeld C, Englert H, Piepke M, Dress RJ, Oertel M, Fischer T, Hackbusch R, Zha M, Cai H, Casar C, Schädlich IS, Winter L, Jander A, Degenhardt K, Bester M, Flottmann F, Hanning U, Holst B, Worthman A, Hiefner J, Rutz B, Schlemm E, Thomalla G, Clausen BH, Stowe AM, Prinz I, Arumugam TV, Glatzel M, Renné T, Fiehler J, Tolosa E, Magnus T, Gelderblom M.   +33 more
europepmc   +1 more source

Serum amyloid A triggers the mosodium urate -mediated mature interleukin-1β production from human synovial fibroblasts [PDF]

Background: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1β (IL-1β) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ...
Nakamura, Minoru, Nakamura, Tadashi, Kawakami, Atsushi, Migita, Kiyoshi, Izumi, Masahiro, Maeda, Yumi, Motokawa, Satoru, Jiuchi, Yuka, Aiba, Yoshihiro, Torigoshi, Takafumi, Miyashita, Taiichiro, Koga, Tomohiro, Satomura, Kenshi, Yamasaki, Satoshi, Ishibashi, Hiromi, Komori, Atsumasa, Izumi, Yasumori   +16 more
core  

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Upregulation of interleukin-1β and interleukin-18 in traumatic brain injury patients and their potential as biomarkers. [PDF]

PLoS One
Nazeer S, Murtaza G.
europepmc   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Severe Gout During Arsenic Therapy: Insights on Oxidative Stress and Interleukin-1β in Gout. [PDF]

ACR Open Rheumatol
Hamilton J, Alexander A.
europepmc   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats. [PDF]

Iran J Med Sci
Pourfarzad K, Soori R, Hamedchaman N, Riahy S.   +3 more
europepmc   +1 more source