Results 251 to 260 of about 441,815 (305)

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling. [PDF]

Mol Cell Biochem
Beaumont RE, Smith EJ, Zhou L, Marr N, Thorpe CT, Guest DJ.   +5 more
europepmc   +1 more source

Interleukin-6 and interleukin-1 beta polymorphisms in allergic contact eczema

, 2018
Westphal, Goetz Alexander, Schnuch, Axel, Neumann, C., Hallier, Ernst, Reich, Kristian   +4 more
openaire   +1 more source

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Human interleukin-1 beta gene

Gene, 1987
We report the nucleotide sequence of the human chromosomal gene which encodes the interleukin-1 beta protein (IL-1 beta). The gene spans a region of 7.5 kb and the coding part is divided into seven exons. Comparison with the homologous mouse gene reveals that the structural organization is conserved through evolution.
Bensi G, RAUGEI, GIOVANNI, Palla E, Carinci V, Tornese Buonamassa D, Melli M.   +5 more
openaire   +3 more sources

Interleukin 1 alpha and an interleukin 1 beta fragment are somnogenic

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1990
The somnogenic activity of interleukin 1 beta (IL-1 beta) has previously been established. Interleukin 1 alpha (IL-1 alpha) is a distinct gene product that possesses similar biological activities. We report here that IL-1 alpha, like IL-1 beta, has the capacity in rabbits to enhance non-rapid-eye-movement sleep, electroencephalographic slow-wave (0.5 ...
F, Obal, M, Opp, A B, Cady, L, Johannsen, A E, Postlethwaite, H M, Poppleton, J M, Seyer, J M, Krueger   +7 more
openaire   +2 more sources

Interleukin-1 beta gene polymorphisms and preterm birth

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012
To investigate the association between two genetic variations in the Interleukin-1 beta (IL1B) gene and preterm birth.In this case-control study we tested the allelic distribution of two of its common polymorphisms (IL1B +3953C>T [rs1143634], IL1B -511C>T [rs16944]) in one hundred women with preterm birth and one hundred healthy women with at least one
Maximilian, Schmid, Peter, Haslinger, Susanne, Stary, Heinz, Leipold, Christian, Egarter, Christoph, Grimm   +5 more
openaire   +2 more sources

Plasma interleukin-1 beta concentrations in panic disorder

Psychiatry Research, 1994
Plasma interleukin-1 beta (IL-1 beta) concentrations were measured in 10 outpatients with panic disorder before and on days 30 and 32 of treatment with alprazolam (2-2.5 mg/day). IL-1 beta concentrations were found to be significantly higher in patients than in control subjects both before and during therapy.
F. BRAMBILLA, L. BELLODI, G. PERNA, A. BERTANI, A.E. PANERAI, P. SACERDOTE   +5 more
openaire   +2 more sources

Conformation, stability, and folding of interleukin 1.beta.

Biochemistry, 1987
Recombinant human interleukin 1 beta has been studied in solution with respect to its conformation, stability, and characteristics of unfolding and refolding. It is an all-beta-type, stable globular protein with a high cooperativity under conditions where refolding is reversible.
S, Craig, U, Schmeissner, P, Wingfield, R H, Pain   +3 more
openaire   +2 more sources