Results 61 to 70 of about 441,815 (305)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Serum Inflammatory Factor Profiles in the Pathogenesis of High-Altitude Polycythemia and Mechanisms of Acclimation to High Altitudes

Mediators of Inflammation, 2021
High-altitude polycythemia (HAPC) is a common aspect of chronic mountain sickness (CMS) caused by hypoxia and is the main cause of other symptoms associated with CMS. However, its pathogenesis and the mechanisms of high-altitude acclimation have not been
Hai Yi, Qianjin Yu, Dongfeng Zeng, Zhaohua Shen, Jiali Li, Lidan Zhu, Xi Zhang, Quanhong Xu, Hu Song, Peiyan Kong   +9 more
doaj   +1 more source

Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]

, 2017
Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed, Crowe, Lindsay A.N., Garcia-Melchor, Emma, Gilchrist, Derek S., Kerr, Shauna C., Kitson, Susan M., McInnes, Iain B., Millar, Neal L., Murrell, George A.C., Nelis, Briana, Reilly, James H.   +10 more
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Connection between genetic polymorphism of interleukin -1 beta with chronic periodontitis in peruvian adults

Revista Peruana de Medicina Experimental y Salud Pública, 2018
Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study.
Ivonne F. Reyes-Mandujano, José E. Olivera-García, Manuel Taboada-Vega, Patricia Galvan-Sanchez, Amilcar Azcarza-Acuña, Aldo M. Yactayo-Flores, Luis A. Zuñiga-Ccoicca, Evelyn V. Leiva-Pachas, Efraín Paccori-García   +8 more
doaj   +1 more source

MEMAHAMI INTERLEUKIN 1 BETA SEBAGAI SITOKIN PROINFLAMASI

Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan, 2023
Interleukin-1 (IL-1) awalnya dijelaskan pada tahun 1940an sebagai protein pemicu demam yang dilepaskan oleh leukosit yang diaktifkan. Pada waktu itu disebut “pirexin” atau “pyrogen endogen”. Interleukin-1 adalah sebuah sitokin inflamasi yang dianggap memiliki beragam fungsi fisiologis dan signifikansi patologis dan memainkan peran penting dalam ...
null Andi Ita Maghfirah, null Tenri Esa, null Uleng Bahrun   +2 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Differential effects of interleukin-1 alpha and interleukin-1 beta on human peripheral blood eosinophils [PDF]

Blood, 1989
Interleukin-1 (IL-1) plays a major role in the response to infection, inflammation, and immunological challenge. Eosinophils participate in the host response to parasitic infection and allergic and hypersensitivity diseases. The role of IL-1 in these disease states has not been extensively explored. We have reported that purified human monocyte derived
E A, Whitcomb, C A, Dinarello, S H, Pincus   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Relationship between interleukin 1beta and virulence factors produced by some bacteria isolated from patients with sinus infections

Tikrit Journal of Pure Science
Background: Sinusitis is an inflammatory process of the mucosa lining the paranasal cavity. Currently, the term rhinosinusitis has been more accepted because rhinitis and sinusitis are continuous diseases.
Shiamaa Al-Khazali, Suha Mahir, Mohanad Hasan   +2 more
doaj   +1 more source