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Annual Review of Medicine, 1986
Interleukins are polypeptides that act on leukocytes and other tissue targets. Interleukin-1, produced by macrophages and other cells, activates lymphocytes and also induces several components of the host's acute-phase response to infection and injury. Interleukin-2, produced by T lymphocytes, is a growth factor for helper, suppressor, and cytotoxic T ...
C A, Dinarello, J W, Mier
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Interleukins are polypeptides that act on leukocytes and other tissue targets. Interleukin-1, produced by macrophages and other cells, activates lymphocytes and also induces several components of the host's acute-phase response to infection and injury. Interleukin-2, produced by T lymphocytes, is a growth factor for helper, suppressor, and cytotoxic T ...
C A, Dinarello, J W, Mier
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Interleukin 1: the first interleukin
Immunology Today, 1990The name 'interleukin' and the designation of interleukin 1 (IL-1) derived from the Second International Lymphokine Workshop held in Switzerland in 1979. Since then interest in the original interleukin (IL-1) has increased exponentially as measured by the numbers of publications and meetings.
F S, di Giovine, G W, Duff
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Biotherapy, 1990
Interleukin-3 (IL-3) is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells. In five mammalian species, including man, the gene encoding IL-3 has been isolated and expressed to yield the mature recombinant proteins.
G, Wagemaker +4 more
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Interleukin-3 (IL-3) is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells. In five mammalian species, including man, the gene encoding IL-3 has been isolated and expressed to yield the mature recombinant proteins.
G, Wagemaker +4 more
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International Reviews of Immunology, 1998
The particular interest of IL-17, a homodimeric cytokine of about 32 kDa, is the strict requirement for an activation signal to induce its expression from a rather restricted set of cells, human memory T cells or mouse alpha beta TCR+CD4-CD8- thymocytes.
F, Fossiez +5 more
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The particular interest of IL-17, a homodimeric cytokine of about 32 kDa, is the strict requirement for an activation signal to induce its expression from a rather restricted set of cells, human memory T cells or mouse alpha beta TCR+CD4-CD8- thymocytes.
F, Fossiez +5 more
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Leukemia & Lymphoma, 1994
Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors.
S, Kobayashi +3 more
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Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors.
S, Kobayashi +3 more
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Seminars in Immunology, 2013
Although the IL-1α molecule has long been recognized, information about its distinct role in various diseases is limited, since most clinical studies have focused on the role of IL-1β. Despite triggering the same IL-1 receptor as does IL-1β, there is, however, a distinct role for IL-1α in some inflammatory diseases.
Peleg, Rider +3 more
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Although the IL-1α molecule has long been recognized, information about its distinct role in various diseases is limited, since most clinical studies have focused on the role of IL-1β. Despite triggering the same IL-1 receptor as does IL-1β, there is, however, a distinct role for IL-1α in some inflammatory diseases.
Peleg, Rider +3 more
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Annual Review of Immunology, 1984
In the past year there have been significant advances in understanding the role of interleukin-2. Its role in the activation of T cells by antigen-presenting cells, the structure-activity relationships between interleukin-2 and its receptor and the subsequent signaling have all become clearer.
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In the past year there have been significant advances in understanding the role of interleukin-2. Its role in the activation of T cells by antigen-presenting cells, the structure-activity relationships between interleukin-2 and its receptor and the subsequent signaling have all become clearer.
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Seminars in Immunology, 2013
IL-37 was formerly termed IL-1 family member 7. The cytokine was discovered by in silico research of human databases. Although there are no genes in the databases with an open reading frame for a murine homologue for IL-37, human IL-37 is functional in the mouse. Like others members of the IL-1 family, IL-37 lacks a signal peptide.
Dinarello, C.A., Bufler, P.
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IL-37 was formerly termed IL-1 family member 7. The cytokine was discovered by in silico research of human databases. Although there are no genes in the databases with an open reading frame for a murine homologue for IL-37, human IL-37 is functional in the mouse. Like others members of the IL-1 family, IL-37 lacks a signal peptide.
Dinarello, C.A., Bufler, P.
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The International Journal of Biochemistry & Cell Biology, 1998
Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades.
E, Stylianou, J, Saklatvala
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Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades.
E, Stylianou, J, Saklatvala
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Archives of Dermatology, 1989
The last decade has witnessed a remarkable expansion in the understanding of the skin as an immunologic organ. A prime example of this is the discovery that keratinocytes can synthesize and secrete immunoregulatory and proinflammatory glycoproteins termed cytokines.
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The last decade has witnessed a remarkable expansion in the understanding of the skin as an immunologic organ. A prime example of this is the discovery that keratinocytes can synthesize and secrete immunoregulatory and proinflammatory glycoproteins termed cytokines.
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