Results 141 to 150 of about 387,713 (336)

Funder-Intermediary Relationships: Promise & Pitfalls [PDF]

open access: yes, 2008
A growing body of work is being undertaken by foundations with the help of intermediary organizations. For a funder, working with an intermediary has the potential to greatly enhance the funder's impact with their constituents, bringing needed expertise,
Kate Murphy
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Innovation in Financial Services, Relationships and Risk Sharing [PDF]

open access: yes
Relationships between intermediaries and their customers have become increasingly important in recent years. This paper argues that the need for costly ex ante information acquisition and analysis is a major barrier to the participation of investors and ...
Douglas Gale, H. Franklin Allen
core  

Positioning of systemic intermediaries in sustainability transitions: Between storylines and speech acts

open access: yesEnvironmental Innovation and Societal Transitions, 2020
Harro van Lente, W. Boon, L. Klerkx
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Trade through endogenous intermediaries [PDF]

open access: yes
We apply an intermediation game of Townsend (1983) to analyze trade in an exchange economy through endogenous intermediaries. In this game, each trader has the opportunity to become an intermediary by oering to buy or sell unlimited quantities of the ...
Kilenthong, Weerachart, Qin, Cheng-Zhong
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Analysis of Effectiveness of Various Channels for Selling Agricultural Products [PDF]

open access: yesProblemi Ekonomiki, 2018
The aim of the article is to conduct an analysis of the agricultural products market in Ivano-Frankivsk region by assessing the main channels for selling products and the price level.
Yakubiv Valentyna М.   +1 more
doaj  

Conceptualising the systemic activities of intermediaries in sustainability transitions

open access: yesEnvironmental Innovation and Societal Transitions, 2020
W. Kanda   +3 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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