Results 51 to 60 of about 57,834 (304)

Un acercamiento a las figuras de agentes de negocios y procuradores de Indias en la Corte

open access: yesNuevo mundo - Mundos Nuevos, 2017
We're interested in processes to "overcome distance" in an imperial context. In studying two unknown figures of political and social mediation, the procuradores generales and the agentes de negocios de Indias in Madrid, we put forward the role of the ...
Guillaume Gaudin
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Indigenous intermediaries : new perspectives on exploration archives /

open access: yes
This edited collection understands exploration as a collective effort and experience involving a variety of people in diverse kinds of relationships.
Nugent, Maria,editor.   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Channelling through bureaucracy : How migration intermediaries and state actors (re)shape Chinese migration to the Swedish restaurant industry

open access: yes, 2021
The role of migration mediation in the global circulation of labour has been receiving increasing attention. Channel is a frequently used, but under-theorised, concept in such studies.
Zhang, Qian,, Axelsson, Linn,
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Intermediation in Foreign Trade: When Do Exporters Rely on Intermediaries? [PDF]

open access: yes
The paper explores theoretically and empirically why trade intermediaries (TIs) are frequently used as agents for exports to some countries but not to others. We adapt a standard intra-industry trade model with variable export costs (e.g.
Parvati Trübswetter   +2 more
core   +2 more sources

(De)Constructing the Disruption: Enacted Sensemaking and Sensegiving in Institutionally Plural Fields

open access: yesJournal of Organizational Sociology
If an event happens in the woods, and nobody responds to it, is it a disruption? In this paper, we address a gap in the organizational sociology literature about how events are constructed as “institutional disruptions” in institutionally plural fields ...
Kumar Amal, Higgins Monica C.
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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