Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Exploring the contributions of open data intermediaries for a sustainable open data ecosystem
Data & PolicyOpen data promises various benefits, including stimulating innovation, improving transparency and public decision-making, and enhancing the reproducibility of scientific research.
Ashraf Shaharudin +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The importance of Intermediaries organizations in international R&D cooperation: an empirical multivariate study across Europe [PDF]
Despite the large number of publications related to business cooperation in R&D and the wide perception of the importance of intermediary institutions in the R&D cooperation process, empirical studies on its role are scarce, scattered and fragmented ...
Aurora A. C. Teixeira +1 more
core
Producing (im)mobilities in home care for the elderly: the role of home care agencies in Switzerland
International Journal of Ageing and Later Life, 2019 The Free Movement of Persons Agreement has fostered the emergence of a new market for live-in care in Switzerland. Private care agencies recruit women from the European Union (EU) accession states and place them as live-in carers for the elderly in ...
Huey Shy Chau
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
50 Years of Research in Real Estate Brokerage: A Semi-Systematic Literature Review
Real EstateIntermediaries are central to complex transactions. In housing markets, real estate brokers coordinate information flows, reduce search costs, and guide lay buyers and sellers through legal and financial steps.
Martin Ahlenius +2 more
doaj +1 more source
Intermediaries and the Market: Hans Rottenhammer’s Use of Networks in the Copper Painting Market
Arts, 2019 In Willem van Haecht’s Gallery of Cornelis van der Geest, The Last Judgment by the German artist Hans Rottenhammer stands prominently in the foreground.
Sophia Quach McCabe
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Journal of International Studies, 2019 This study intended to investigate factors that influence the relationship quality between Malaysia SME exporters and foreign intermediaries.
Norliza Hamir Basah
doaj +1 more source