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Functions of intermediate filaments
Cell Motility, 1989Intermediate filaments (IFs) are the most enigmatic component of the eukaryotic cytoskeleton. IFs are often a major component of the cell and are most prominent in the cells of vertebrates. Ultrastructurally similar cytoplasmic filaments have been found in many metazoan phylla and some protists and homologous proteins form the nuclear lamina, a fibrous
M W, Klymkowsky +2 more
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Intermediate filaments in disease
Current Opinion in Cell Biology, 1995Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as ...
W H, McLean, E B, Lane
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Intermediate Filament Associated Proteins
2005Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle.
Kathleen J, Green +3 more
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Intermediate filament molecular biology
Current Biology, 1992Epidermal keratin intermediate filaments appear to have a structural function. The functions of other intermediate filaments are being elucidated using a combination of molecular genetic methods, including the expression of dominant negative mutant proteins and gene targeting.
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Intermediate filament-related myopathies
Pediatric Neurology, 2001The dynamic and critical role of intermediate filaments in muscle is highlighted by myopathies characterized by aberrant accumulation of intermediate filaments. In some affected patients, mutations in genes encoding intermediate filaments that are expressed in muscle have been confirmed.
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Cytoskeletal Intermediate Filaments: Practical Applications of Intermediate Filament Analysis
Ultrastructural Pathology, 1987J W, Bolen, M A, McNutt
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Post-translational modifications of intermediate filament proteins: mechanisms and functions
Nature Reviews Molecular Cell Biology, 2014Natasha T Snider, M Bishr Omary
exaly