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Intermediate filaments in disease

Current Opinion in Cell Biology, 1995
Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as ...
W H, McLean, E B, Lane
openaire   +2 more sources

Intermediate Filament Associated Proteins

2005
Intermediate filament associated proteins (IFAPs) coordinate interactions between intermediate filaments (IFs) and other cytoskeletal elements and organelles, including membrane-associated junctions such as desmosomes and hemidesmosomes in epithelial cells, costameres in striated muscle, and intercalated discs in cardiac muscle.
Kathleen J, Green   +3 more
openaire   +2 more sources

Intermediate filament molecular biology

Current Biology, 1992
Epidermal keratin intermediate filaments appear to have a structural function. The functions of other intermediate filaments are being elucidated using a combination of molecular genetic methods, including the expression of dominant negative mutant proteins and gene targeting.
openaire   +2 more sources

Intermediate filament-related myopathies

Pediatric Neurology, 2001
The dynamic and critical role of intermediate filaments in muscle is highlighted by myopathies characterized by aberrant accumulation of intermediate filaments. In some affected patients, mutations in genes encoding intermediate filaments that are expressed in muscle have been confirmed.
openaire   +2 more sources

Intermediate filament structure: the bottom-up approach.

Current Opinion in Cell Biology, 2015
A. Chernyatina, D. Guzenko, S. Strelkov
semanticscholar   +1 more source

Evolutionary aspects in intermediate filament proteins.

Current Opinion in Cell Biology, 2015
A. Peter, R. Stick
semanticscholar   +1 more source

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