Results 281 to 290 of about 160,868 (310)
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Neuronal Intermediate Filaments
Annual Review of Neuroscience, 1996Neurofilaments (NFs) are the most abundant structural components in large-diameter myelinated axons. Assembled as obligate heteropolymers requiring NF-L and substoichiometric amounts of NF-M and/or NF-H, NF investment into axons is essential for establishment of axonal caliber, itself a key determinant of conduction velocity.
M K, Lee, D W, Cleveland
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Intermediate filament dynamics
Cell, 1990Article synthese sur le role des filaments intermediaires dans la dynamique cellulaire; implications dans le ...
P M, Steinert, R K, Liem
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Intermediate filament structure
Current Opinion in Cell Biology, 1992In the past year, several new developments concerning the structure of intermediate filament proteins and their assembly into intact intermediate filaments have been made: the coiled-coil structure of a rod domain has been elucidated; the basis of the chain interaction and its role in intermediate filament assembly has been specified; the organization ...
D A, Parry, P M, Steinert
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Intermediate filament dynamics
Current Opinion in Cell Biology, 1992The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place.
J E, Eriksson, P, Opal, R D, Goldman
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Current Opinion in Cell Biology, 1989
It is likely that future studies involving a molecular biology approach, similar to those described in [7,27,28], will yield fruitful information regarding properties and cellular roles of IF. At this point, our knowledge of the properties and expression of IF remains in stark contrast to our lack of understanding of their biological functions.
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It is likely that future studies involving a molecular biology approach, similar to those described in [7,27,28], will yield fruitful information regarding properties and cellular roles of IF. At this point, our knowledge of the properties and expression of IF remains in stark contrast to our lack of understanding of their biological functions.
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Neuronal Intermediate Filaments
Current Opinion in Cell Biology, 1990Neuronal intermediate filaments (IFs) are 10–12-nm filaments that are expressed in the nervous system. IF proteins belong to a large gene family and the expression of different IF proteins is tissue specific. In the nervous system, different neuronal IFs are expressed in neuroepithelial stem cells, the central nervous system, and peripheral nervous ...
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Neurology, 2002
In this issue of Neurology, Kulhenbaumer et al.1 describe novel mutations of the gene responsible for giant axonal neuropathy (GAN). GAN, a recessive multisystem disorder, presents with a variable phenotype that includes tightly curled hair, CNS involvement, and a progressive sensorimotor axonal neuropathy.2 GAN is an especially instructive reminder of
David N. Herrmann, John W. Griffin
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In this issue of Neurology, Kulhenbaumer et al.1 describe novel mutations of the gene responsible for giant axonal neuropathy (GAN). GAN, a recessive multisystem disorder, presents with a variable phenotype that includes tightly curled hair, CNS involvement, and a progressive sensorimotor axonal neuropathy.2 GAN is an especially instructive reminder of
David N. Herrmann, John W. Griffin
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Assembly of intermediate filaments
BioEssays, 1993AbstractThe assembly of intermediate filaments is a fundamental property of the central rod domain of the individual subunit proteins. This rod domain, with its high propensity for α‐helix formation, is the common and identifying feature of this family of proteins. Assembly occurs in vitro in the absence of other proteins or exogenous sources of energy;
Shoeman, R., Traub, P.
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Functions of intermediate filaments
Cell Motility, 1989Intermediate filaments (IFs) are the most enigmatic component of the eukaryotic cytoskeleton. IFs are often a major component of the cell and are most prominent in the cells of vertebrates. Ultrastructurally similar cytoplasmic filaments have been found in many metazoan phylla and some protists and homologous proteins form the nuclear lamina, a fibrous
M W, Klymkowsky +2 more
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Intermediate filaments in disease
Current Opinion in Cell Biology, 1995Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as ...
W H, McLean, E B, Lane
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