Results 1 to 10 of about 43,204 (229)

Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene

Biology Open, 2016
The transcription factor Nkx2.5 and the intermediate filament protein desmin are simultaneously expressed in cardiac progenitor cells during commitment of primitive mesoderm to the cardiomyogenic lineage.
Christiane Fuchs, Sonja Gawlas, Philipp Heher, Sofia Nikouli, Hannah Paar, Mario Ivankovic, Martina Schultheis, Julia Klammer, Teresa Gottschamel, Yassemi Capetanaki, Georg Weitzer   +10 more
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Novel Desmin Mutation Causing Myofibrillar Myopathy in a Hmong Family

Frontiers in Neurology, 2020
Myofibrillar myopathies (MFM) are a clinically and genetically heterogenous group of inherited myopathies characterized by aggregation of Z-disc proteins. Mutations in desmin account for ~7% of MFM.
Stefan Nicolau, Benjamin M. Howe, Elie Naddaf   +2 more
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Impaired Autophagic Flux in Skeletal Muscle of Plectin‐Related Epidermolysis Bullosa Simplex With Muscular Dystrophy

Journal of Cachexia, Sarcopenia and Muscle
Background Plectin, a multifunctional cytolinker and intermediate filament stabilizing protein, is essential for muscle fibre integrity and function. Mutations in the human plectin gene (PLEC) cause autosomal recessive epidermolysis bullosa simplex with ...
Michaela M. Zrelski, Margret Eckhard, Petra Fichtinger, Sabrina Hösele, Andy Sombke, Leonid Mill, Monika Kustermann, Wolfgang M. Schmidt, Fiona Norwood, Ursula Schlötzer‐Schrehardt, Gerhard Wiche, Rolf Schröder, Lilli Winter   +12 more
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Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles

Biomolecules, 2020
Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted metalloproteinase with catalytic activity against versican, is implicated in myogenesis and ...
Alex B. Addinsall, Leonard G. Forgan, Natasha L. McRae, Rhys W. Kelly, Penny L. McDonald, Bryony McNeill, Daniel R. McCulloch, Nicole Stupka   +7 more
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Desmin: molecular interactions and putative functions of the muscle intermediate filament protein

Brazilian Journal of Medical and Biological Research, 2004
Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells. There are other IF proteins in muscle such as nestin, peripherin, and vimentin, besides the ubiquitous lamins, but they are not unique to muscle ...
M.L. Costa, R. Escaleira, A. Cataldo, F. Oliveira, C.S. Mermelstein   +4 more
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Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation

Cells
In muscle cells subjected to mechanical stimulation, LINC complex and cytoskeletal proteins are basic to preserve cellular architecture and maintain nuclei orientation and positioning. In this context, the role of lamin A/C remains mostly elusive.
Vittoria Cenni, Camilla Evangelisti, Spartaco Santi, Patrizia Sabatelli, Simona Neri, Marco Cavallo, Giovanna Lattanzi, Elisabetta Mattioli   +7 more
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Sodium hydrogen sulfide (NaHS) ameliorates alterations caused by cisplatin in filtration slit diaphragm and podocyte cytoskeletal in rat kidney [PDF]

Journal of Nephropathology, 2017
Background: Hydrogen sulfide (H2S) has been shown to have a protective role in various kidney disorders. Objectives: This study investigated the molecular mechanism of NaHS (a H2S donor) in treating on the renal damage induced by cisplatin (CP).Materials
Asiyeh Karimi, Forouzan Absalan, layasadat Khorsandi, Armita Valizadeh, Esrafil Mansouri   +4 more
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Cardiomyopathies associated with the DES gene mutations: molecular pathogenesis and gene therapy approaches

Alʹmanah Kliničeskoj Mediciny, 2019
Cardiomyopathy (CMP) is a common group of cardiovascular disorders. Genetic (primary) cardiomyopathies are related to abnormalities in more than 100 genes, including the DES gene encoding desmin protein.
K. S. Kochergin-Nikitsky, E. V. Zaklyazminskaya, A. V. Lavrov, S. A. Smirnikhina   +3 more
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Morphologic and Morphometric Study of the Heart and Its Great Arteries in the Common Pheasant (Phasianus colchicus)

Veterinary Medicine and Science
This study investigates the morphological and morphometric characteristics of the heart and great arteries in the common pheasant (Phasianus colchicus). Five adult male bird were used.
Hadis Ramezani, Nader Goodarzi
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Effects of an immunosuppressive treatment on the rat prostate

Drug Design, Development and Therapy, 2016
Marta Grabowska,1 Karolina Kędzierska,2 Katarzyna Michałek,3 Sylwia Słuczanowska-Głąbowska,4 Maciej Grabowski,5 Małgorzata Piasecka,1 Andrzej Kram,6 Iwona Rotter,7 Aleksandra Rył,1 Maria Laszczyńska1 1Department of Histology and Developmental Biology ...
Grabowska M, Kędzierska K, Michałek K, Słuczanowska-Głąbowska S, Grabowski M, Piasecka M, Kram A, Rotter I, Rył A, Laszczyńska M   +9 more
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