Results 1 to 10 of about 35,458 (213)

Desmin-p.L112Q Disturbs Filament Formation and Is a Likely-Pathogenic Variant Associated with Dilated Cardiomyopathy [PDF]

Journal of Cardiovascular Development and Disease
DES encodes the muscle-specific intermediate filament protein desmin, which is highly relevant to the structural integrity of cardiomyocytes. Mutations in this gene cause different cardiomyopathies including dilated cardiomyopathy.
Alexander Lütkemeyer, Sabrina Voß, Jonas Reckmann, Joline Groß, Anna Gärtner, Jan Gummert, Hendrik Milting, Andreas Brodehl   +7 more
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Desmin variants: Trigger for cardiac arrhythmias?

Frontiers in Cell and Developmental Biology, 2022
Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su, Wei Su, Stan W. van Wijk, Stan W. van Wijk, Bianca J. J. M. Brundel, Bianca J. J. M. Brundel   +5 more
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Desmin Reorganization by Stimuli Inducing Oxidative Stress and Electrophiles: Role of Its Single Cysteine Residue

Antioxidants, 2023
The type III intermediate filament proteins vimentin and GFAP are modulated by oxidants and electrophiles, mainly through perturbation of their single cysteine residues.
Diego Moneo-Corcuera, Álvaro Viedma-Poyatos, Konstantinos Stamatakis, Dolores Pérez-Sala   +3 more
doaj   +1 more source

Global O-GlcNAcylation changes impact desmin phosphorylation and its partition toward cytoskeleton in C2C12 skeletal muscle cells differentiated into myotubes

Scientific Reports, 2022
Desmin is the guardian of striated muscle integrity, permitting the maintenance of muscle shape and the efficiency of contractile activity. It is also a key mediator of cell homeostasis and survival.
Charlotte Claeyssen, Bruno Bastide, Caroline Cieniewski-Bernard   +2 more
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The In Vitro Cytotoxic Effects of Ionophore Exposure on Selected Cytoskeletal Proteins of C2C12 Myoblasts

Toxins, 2022
Carboxylic ionophores, such as monensin, salinomycin and lasalocid, are polyether antibiotics used widely in production animals for the control of coccidiosis, as well as for the promotion of growth and feed efficiency.
Danielle Henn, Annette Venter, Gezina C. H. Ferreira, Christo J. Botha   +3 more
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Multiple sites in αB-crystallin modulate its interactions with desmin filaments assembled in vitro. [PDF]

PLoS ONE, 2011
The β3- and β8-strands and C-terminal residues 155-165 of αB-crystallin were identified by pin arrays as interaction sites for various client proteins including the intermediate filament protein desmin.
Scott A Houck, Andrew Landsbury, John I Clark, Roy A Quinlan   +3 more
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Congenital sacrococcygeal rhabdomyosarcoma

African Journal of Paediatric Surgery, 2022
Rhabdomyosarcoma (RMS) is one of the common malignant soft-tissue sarcomas affecting children. It originates from the embryonic mesenchyme precursor of striated muscle and is frequently seen in the head-and-neck region, genitourinary system and ...
Renuka Venkata Inuganti, Amulya Boddapati, Atchyuta Mathi, Rizwana Shaik   +3 more
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Drosophila Nesprin-1 Isoforms Differentially Contribute to Muscle Function

Cells, 2021
Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning.
Alexandre Rey, Laurent Schaeffer, Bénédicte Durand, Véronique Morel   +3 more
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Promising Antifungal Activity of Encephalartos laurentianus de Wild against Candida albicans Clinical Isolates: In Vitro and In Vivo Effects on Renal Cortex of Adult Albino Rats

Journal of Fungi, 2022
Candida albicans can cause various infections, especially in immunocompromised patients. Its ability to develop resistance to the current antifungal drugs as well as its multiple virulence factors have rendered the problem even more complicated. Thus, in
Walaa A. Negm, Mona El-Aasr, Ghada Attia, Moneerah J. Alqahtani, Rania Ibrahim Yassien, Amal Abo Kamer, Engy Elekhnawy   +6 more
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Spatial Fuzzy C-means dan Rapid Region Merging untuk Pemisahan Sel Kanker Payudara

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017
Segmentation and overlapped cells separation are important phases in microscopic image processing of breast cancer, because the accuracy of overlapped cells separation result determines the accuracy of breast cancer cell calculation. The amount of breast
Desmin Tuwohingide, Chastine Fatichah
doaj   +1 more source