Stromal-Derived IL-8 Promotes M2 Macrophage Polarization via the RhoA/MRTF-A/SRF Transcriptional Axis to Impair CD8<sup>+</sup> T Cell Cytotoxicity in Lung Cancer. [PDF]
Adv Sci (Weinh)In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Gu X +7 more
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A cytoplasmic escapee: desmin is going nuclear
, 2021 It has been a long time since researchers have focused on the cytoskeletal proteins' unconventional functions in the nucleus. Subcellular localization of a protein not only affects its functions but also determines the accessibility for cellular ...
Kural Mangit, Ecem +4 more
core +1 more source
Diverse Presentations of Angiomyxomas: A Series of Three Cases [PDF]
National Journal of Laboratory MedicineAngiomyxomas are uncommon mesenchymal tumours that typically arise in the vulvovaginal and pelvic regions of women and only rarely in men. Their indolent growth and resemblance to other soft-tissue lesions often complicate clinical diagnosis. We describe
Kundhavai Chandrasekaran +2 more
doaj +1 more source
Is Desmin Propensity to Aggregate Part of its Protective Function?
Cells, 2020 Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF).
Sonia R. Singh +4 more
doaj +1 more source
Immunocytochemical characteristics of submucosal uterine myomas [PDF]
Vojnosanitetski Pregled, 2010 Background/Aim. Myomas of the uterus, the most common benign tumors, have been studied for decades from the aspects of different basic and clinical disciplines. Despite this fact, their pathogenesis is still poorly understood.
Mladenović-Mihailović Aleksandra +5 more
doaj +1 more source
Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1
Molecular Therapy: Nucleic Acids, 2023 Exon-skipping therapy is a promising treatment strategy for Duchenne muscular dystrophy (DMD), which is caused by loss-of-function mutations in the DMD gene encoding dystrophin, leading to progressive cardiomyopathy. In-frame deletion of exons 3–9 (Δ3–9),
Naoko Shiba +18 more
doaj +1 more source
Immunohistochemical distribution of desmin in the human fetal heart
, 2011 Desmin is a member of the intermediate filaments, which play crucial roles in the maturation, maintenance and recovery of muscle fibers. Its expression has been examined in human cardiac muscle, rat and chicken, but its spatial distribution in the human ...
Murakami, Gen +11 more
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Desmin and CD31 immunolabeling for detecting venous invasion of the pancreatobiliary tract cancers.
PLoS ONE, 2020 Although venous invasion (VI) is a poor prognostic factor for patients with pancreatobiliary tract cancers, its histopathologic characteristics have not been well described.
Junyoung Shin +3 more
doaj +1 more source
Ovarian Leiomyoma Along with Uterine Leiomyomata: A Common Tumour at an Uncommon Site [PDF]
Journal of Clinical and Diagnostic Research, 2015 Ovarian leiomyoma is one of the rarest benign tumours of the ovary, mostly seen in women of reproductive age group. Here we report a case of ovarian leiomyoma as an incidental finding in a patient of 38-year-old woman with uterine leiomyomata ...
Indira Gunasekaran +3 more
doaj +1 more source
Lack of Desmin in Mice Causes Structural and Functional Disorders of Neuromuscular Junctions
Frontiers in Molecular Neuroscience, 2020 Desmin, the major intermediate filament (IF) protein in muscle cells, interlinks neighboring myofibrils and connects the whole myofibrillar apparatus to myonuclei, mitochondria, and the sarcolemma.
Nane Eiber +11 more
doaj +1 more source