Cell Death Discovery, 2021 Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates
Marion Bouvet +11 more
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Case report of an exercise training and nutritional intervention plan in a patient with A350P mutation in DES gene. [PDF]
, 2020 Performing a supplementation intervention with creatine and protein, in conjunction with low-intensity endurance and resistance exercise is safe and has a positive effect on the quality of life in a patient with ...
Baar, Keith +3 more
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Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]
, 2014 The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y +8 more
core +1 more source
The cytoskeleton of the electric tissue of Electrophorus electricus, L.
Anais da Academia Brasileira de Ciências, 2000 The electric eel Electrophorus electricus is a fresh water teleost showing an electrogenic tissue that produces electric discharges. This electrogenic tissue is distributed in three well-defined electric organs which may be found symmetrically along both
CLAUDIA DOS SANTOS MERMELSTEIN +2 more
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On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria [PDF]
Human Molecular Genetics, 2003 Recent studies in desmin (-/-) mice have shown that the targeted ablation of desmin leads to pathological changes of the extrasarcomeric intermediate filament cytoskeleton, as well as structural and functional abnormalities of mitochondria in striated muscle. Here, we report on a novel heterozygous single adenine insertion mutation (c.5141_5143insA) in
Rolf, Schröder +14 more
openaire +4 more sources
Alveolar rhabdomyosarcoma in a dog confirmed using myogenin immunohistochemistry: a case report
Veterinární Medicína, 2016 A large mass from the right forelimb of a five-year-old, male, Maltese dog, was resected surgically and examined histopathologically. Grossly, the 4 × 6 cm mass was well-demarcated and firm.
J.K. Park +6 more
doaj +1 more source
Immunocytochemical characteristics of submucosal uterine myomas [PDF]
Vojnosanitetski Pregled, 2010 Background/Aim. Myomas of the uterus, the most common benign tumors, have been studied for decades from the aspects of different basic and clinical disciplines. Despite this fact, their pathogenesis is still poorly understood.
Mladenović-Mihailović Aleksandra +5 more
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Role of protein kinase C in inhibition of renin release caused by vasoconstrictors [PDF]
, 1986 It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal ...
Bauer, C. +7 more
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Desmin Interacts Directly with Mitochondria [PDF]
International Journal of Molecular Sciences, 2020 Desmin intermediate filaments (IFs) play an important role in maintaining the structural and functional integrity of muscle cells. They connect contractile myofibrils to plasma membrane, nuclei, and mitochondria. Disturbance of their network due to desmin mutations or deficiency leads to an infringement of myofibril organization and to a deterioration ...
Dayal, Alexander A. +5 more
openaire +2 more sources
Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1
Molecular Therapy: Nucleic Acids, 2023 Exon-skipping therapy is a promising treatment strategy for Duchenne muscular dystrophy (DMD), which is caused by loss-of-function mutations in the DMD gene encoding dystrophin, leading to progressive cardiomyopathy. In-frame deletion of exons 3–9 (Δ3–9),
Naoko Shiba +18 more
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