Results 1 to 10 of about 25,971 (117)

Pitx2 in Embryonic and Adult Myogenesis

Frontiers in Cell and Developmental Biology, 2017
Skeletal muscle is a heterogeneous tissue that represents between 30 and 38% of the human body mass and has important functions in the organism, such as maintaining posture, locomotor impulse, or pulmonary ventilation.
Lara Rodríguez-Outeiriño, Amelia Arànega, Diego Franco   +2 more
exaly   +3 more sources

Non-regenerative myogenesis in adult skeletal muscles: myofiber death-independent muscle satellite cell expansion [PDF]

Skeletal Muscle
Muscle regeneration processes triggered by injuries following myofiber death have been extensively investigated owing to the availability of suitable in vivo animal models, including disease models.
So-ichiro Fukada, Atsushi Kubo, Takashi Yamada, Takayuki Akimoto   +3 more
doaj   +2 more sources

The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease

Antioxidants, 2022
The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle cause it to continuously produce moderate levels of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS).
Xiaoxiang Hu, Shou-Long Deng, Mingming Chen   +2 more
exaly   +3 more sources

Pitx2 Differentially Regulates the Distinct Phases of Myogenic Program and Delineates Satellite Cell Lineages During Muscle Development

Frontiers in Cell and Developmental Biology, 2022
The knowledge of the molecular mechanisms that regulate embryonic myogenesis from early myogenic progenitors to myoblasts, as well as the emergence of adult satellite stem cells (SCs) during development, are key concepts to understanding the genesis and ...
Felícitas Ramírez de Acuña, Felícitas Ramírez de Acuña, Francisco Hernandez-Torres, Francisco Hernandez-Torres, Francisco Hernandez-Torres, Lara Rodriguez-Outeiriño, Lara Rodriguez-Outeiriño, Jorge N. Dominguez, Jorge N. Dominguez, Lidia Matias-Valiente, Lidia Matias-Valiente, Cristina Sanchez-Fernandez, Cristina Sanchez-Fernandez, Diego Franco, Diego Franco, Amelia E. Aranega, Amelia E. Aranega   +16 more
doaj   +1 more source

miR-106b is a novel target to promote muscle regeneration and restore satellite stem cell function in injured Duchenne dystrophic muscle

Molecular Therapy: Nucleic Acids, 2022
Satellite cells (SCs), muscle stem cells, display functional heterogeneity, and dramatic changes linked to their regenerative capabilities are associated with muscle-wasting diseases.
Lara Rodriguez-Outeiriño, Francisco Hernandez-Torres, Felicitas Ramirez de Acuña, Alberto Rastrojo, Carlota Creus, Alejandra Carvajal, Luis Salmeron, Marisol Montolio, Patricia Soblechero-Martin, Virginia Arechavala-Gomeza, Diego Franco, Amelia Eva Aranega   +11 more
doaj   +1 more source

Mitochondrial Oxidative Stress and Mitophagy Activation Contribute to TNF-Dependent Impairment of Myogenesis

Antioxidants, 2023
Many muscular pathologies are associated with oxidative stress and elevated levels of the tumor necrosis factor (TNF) that cause muscle protein catabolism and impair myogenesis.
Daniil A. Chernyavskij, Olga Yu. Pletjushkina, Anastasia V. Kashtanova, Ivan I. Galkin, Anna Karpukhina, Boris V. Chernyak, Yegor S. Vassetzky, Ekaterina N. Popova   +7 more
doaj   +1 more source

TNF Signaling Acts Downstream of MiR-322/-503 in Regulating DM1 Myogenesis

Frontiers in Endocrinology, 2022
Myotonic dystrophy type 1 (DM1) is caused by the expanded CUG repeats and usually displays defective myogenesis. Although we previously reported that ectopic miR-322/-503 expression improved myogenesis in DM1 by targeting the toxic RNA, the underlying ...
Meng Li, Meng Li, Meng Li, Feng Xu, Zhongxian Liu, Zhongxian Liu, Zhongxian Liu, Chunguang Wang, Chunguang Wang, Chunguang Wang, Yun Zhao, Yun Zhao, Yun Zhao, Guoping Zhu, Guoping Zhu, Guoping Zhu, Xiaopeng Shen, Xiaopeng Shen, Xiaopeng Shen   +18 more
doaj   +1 more source

Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model

Frontiers in Cell and Developmental Biology, 2021
Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disease caused by expanded CTG repeats in the 3′ untranslated region (3′UTR) of the DMPK gene.
Xiaopeng Shen, Xiaopeng Shen, Xiaopeng Shen, Zhongxian Liu, Zhongxian Liu, Zhongxian Liu, Chunguang Wang, Chunguang Wang, Chunguang Wang, Feng Xu, Feng Xu, Feng Xu, Jingyi Zhang, Jingyi Zhang, Jingyi Zhang, Meng Li, Meng Li, Meng Li, Yang Lei, Ao Wang, Ao Wang, Ao Wang, Chao Bi, Chao Bi, Chao Bi, Guoping Zhu, Guoping Zhu, Guoping Zhu   +27 more
doaj   +1 more source

Time-resolved phosphoproteome and proteome analysis reveals kinase signaling on master transcription factors during myogenesis

iScience, 2022
Summary: Myogenesis is governed by signaling networks that are tightly regulated in a time-dependent manner. Although different protein kinases have been identified, knowledge of the global signaling networks and their downstream substrates during ...
Di Xiao, Marissa Caldow, Hani Jieun Kim, Ronnie Blazev, Rene Koopman, Deborah Manandi, Benjamin L. Parker, Pengyi Yang   +7 more
doaj   +1 more source

Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook

Nutrition & Metabolism, 2021
Many chronic disease patients experience a concurrent loss of lean muscle mass. Skeletal muscle is a dynamic tissue maintained by continuous protein turnover and progenitor cell activity. Muscle stem cells, or satellite cells, differentiate (by a process
Josiane Joseph, Jason D. Doles
doaj   +1 more source