Results 11 to 20 of about 43,204 (229)

Desmin Modulates Muscle Cell Adhesion and Migration

open access: yesFrontiers in Cell and Developmental Biology, 2022
Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator.
Coralie Hakibilen   +16 more
doaj   +2 more sources

Desmin variants: Trigger for cardiac arrhythmias?

open access: yesFrontiers in Cell and Developmental Biology, 2022
Desmin (DES) is a classical type III intermediate filament protein encoded by the DES gene. Desmin is abundantly expressed in cardiac, skeletal, and smooth muscle cells.
Wei Su   +5 more
doaj   +1 more source

Desmin is not ubiquitously expressed in head and neck muscle fibers. [PDF]

open access: yesJ Anat
Desmin is not ubiquitously expressed in human head and neck muscle fibers. A subset of fibers showed absent or very weak desmin immunoreactivity, with corresponding reduction or absence of desmin mRNA expression. Abstract Desmin, a major muscle‐specific intermediate filament protein, is widely regarded as a ubiquitous component of mature skeletal ...
Stål P, Liu J, Domellöf FP, Shah F.
europepmc   +2 more sources

A Rare Case of Coexisting Mutation in Desmin and Thioredoxin Reductase 2 Genes Causing Dilated Cardiomyopathy [PDF]

open access: yes, 2023
Desmin (DES) maintains the overall structure of cardiomyocytes and cytoskeletal organization within striated muscle cells. Mitochondrial thioredoxin reductase 2 (TXNRD-2) is essential for mitochondrial oxygen radical scavenging.
Khatun, Nazima   +3 more
core   +1 more source

Desmin Reorganization by Stimuli Inducing Oxidative Stress and Electrophiles: Role of Its Single Cysteine Residue

open access: yesAntioxidants, 2023
The type III intermediate filament proteins vimentin and GFAP are modulated by oxidants and electrophiles, mainly through perturbation of their single cysteine residues.
Diego Moneo-Corcuera   +3 more
doaj   +1 more source

The In Vitro Cytotoxic Effects of Ionophore Exposure on Selected Cytoskeletal Proteins of C2C12 Myoblasts

open access: yesToxins, 2022
Carboxylic ionophores, such as monensin, salinomycin and lasalocid, are polyether antibiotics used widely in production animals for the control of coccidiosis, as well as for the promotion of growth and feed efficiency.
Danielle Henn   +3 more
doaj   +1 more source

Global O-GlcNAcylation changes impact desmin phosphorylation and its partition toward cytoskeleton in C2C12 skeletal muscle cells differentiated into myotubes

open access: yesScientific Reports, 2022
Desmin is the guardian of striated muscle integrity, permitting the maintenance of muscle shape and the efficiency of contractile activity. It is also a key mediator of cell homeostasis and survival.
Charlotte Claeyssen   +2 more
doaj   +1 more source

Congenital sacrococcygeal rhabdomyosarcoma

open access: yesAfrican Journal of Paediatric Surgery, 2022
Rhabdomyosarcoma (RMS) is one of the common malignant soft-tissue sarcomas affecting children. It originates from the embryonic mesenchyme precursor of striated muscle and is frequently seen in the head-and-neck region, genitourinary system and ...
Renuka Venkata Inuganti   +3 more
doaj   +1 more source

Drosophila Nesprin-1 Isoforms Differentially Contribute to Muscle Function

open access: yesCells, 2021
Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning.
Alexandre Rey   +3 more
doaj   +1 more source

Promising Antifungal Activity of Encephalartos laurentianus de Wild against Candida albicans Clinical Isolates: In Vitro and In Vivo Effects on Renal Cortex of Adult Albino Rats

open access: yesJournal of Fungi, 2022
Candida albicans can cause various infections, especially in immunocompromised patients. Its ability to develop resistance to the current antifungal drugs as well as its multiple virulence factors have rendered the problem even more complicated. Thus, in
Walaa A. Negm   +6 more
doaj   +1 more source

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