Results 11 to 20 of about 35,458 (213)
Desmin’s conformational modulation by hydrophobicity
Türk Biyokimya DergisiNucleocytoplasmic transport is one of the key features in regulation of cellular physiology. Developing a better understanding of the molecular mechanism underlying the nucleocytoplasmic shuttling of proteins can broaden our perspective and understanding
Kural Mangıt Ecem +2 more
doaj +2 more sources
Brain, 2004 Desmin myopathy is a recently identified disease associated with mutations in desmin or alphaB-crystallin. Typically, the illness presents with lower limb muscle weakness slowly spreading to involve truncal, neck-flexor, facial, bulbar and respiratory muscles.
L G, Goldfarb +3 more
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On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria [PDF]
Human Molecular Genetics, 2003 Recent studies in desmin (-/-) mice have shown that the targeted ablation of desmin leads to pathological changes of the extrasarcomeric intermediate filament cytoskeleton, as well as structural and functional abnormalities of mitochondria in striated muscle. Here, we report on a novel heterozygous single adenine insertion mutation (c.5141_5143insA) in
Rolf, Schröder +14 more
openaire +4 more sources
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Desmin Modulates Muscle Cell Adhesion and Migration
Frontiers in Cell and Developmental Biology, 2022 Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator.
Coralie Hakibilen +16 more
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Embryonal Rhabdomyosarcoma in Middle Ear: A Rare Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2021 Rhabdomyosarcoma (RMS) in middle ear and mastoid are uncommon. Presentation of RMS in these sites include purulent or blood stained discharge, polypoidal mass and granulation tissue.
Anita Omhare +4 more
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The cytoskeleton of the electric tissue of Electrophorus electricus, L.
Anais da Academia Brasileira de Ciências, 2000 The electric eel Electrophorus electricus is a fresh water teleost showing an electrogenic tissue that produces electric discharges. This electrogenic tissue is distributed in three well-defined electric organs which may be found symmetrically along both
CLAUDIA DOS SANTOS MERMELSTEIN +2 more
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Cell Death Discovery, 2021 Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates
Marion Bouvet +11 more
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Alveolar rhabdomyosarcoma in a dog confirmed using myogenin immunohistochemistry: a case report
Veterinární Medicína, 2016 A large mass from the right forelimb of a five-year-old, male, Maltese dog, was resected surgically and examined histopathologically. Grossly, the 4 × 6 cm mass was well-demarcated and firm.
J.K. Park +6 more
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Is Desmin Propensity to Aggregate Part of its Protective Function?
Cells, 2020 Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF).
Sonia R. Singh +4 more
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