Results 11 to 20 of about 57,573 (289)
P234AAV-mediated cardiac transfer of the desmin cDNA ameliorates progression of cardiomyopathy in desmin-deficient mice [PDF]
Gene Therapy, 2014 Mutations of the human desmin (DES) gene cause autosomal dominant and recessive myopathies affecting skeletal and cardiac muscle tissue. Desmin knockout mice (DES-KO), which develop progressive myopathy and cardiomyopathy, mirror rare human recessive desminopathies in which mutations on both DES alleles lead to a complete ablation of desmin protein ...
Manfred Heckmann +6 more
openalex +5 more sources
Desmin’s conformational modulation by hydrophobicity
Türk Biyokimya DergisiNucleocytoplasmic transport is one of the key features in regulation of cellular physiology. Developing a better understanding of the molecular mechanism underlying the nucleocytoplasmic shuttling of proteins can broaden our perspective and understanding
Kural Mangıt Ecem +2 more
doaj +2 more sources
Brain, 2004 Desmin myopathy is a recently identified disease associated with mutations in desmin or alphaB-crystallin. Typically, the illness presents with lower limb muscle weakness slowly spreading to involve truncal, neck-flexor, facial, bulbar and respiratory muscles.
L G, Goldfarb +3 more
openaire +2 more sources
Multiple sites in αB-crystallin modulate its interactions with desmin filaments assembled in vitro. [PDF]
PLoS ONE, 2011 The β3- and β8-strands and C-terminal residues 155-165 of αB-crystallin were identified by pin arrays as interaction sites for various client proteins including the intermediate filament protein desmin.
Scott A Houck +3 more
doaj +1 more source
Congenital sacrococcygeal rhabdomyosarcoma
African Journal of Paediatric Surgery, 2022 Rhabdomyosarcoma (RMS) is one of the common malignant soft-tissue sarcomas affecting children. It originates from the embryonic mesenchyme precursor of striated muscle and is frequently seen in the head-and-neck region, genitourinary system and ...
Renuka Venkata Inuganti +3 more
doaj +1 more source
Drosophila Nesprin-1 Isoforms Differentially Contribute to Muscle Function
Cells, 2021 Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning.
Alexandre Rey +3 more
doaj +1 more source
Journal of Fungi, 2022 Candida albicans can cause various infections, especially in immunocompromised patients. Its ability to develop resistance to the current antifungal drugs as well as its multiple virulence factors have rendered the problem even more complicated. Thus, in
Walaa A. Negm +6 more
doaj +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Spatial Fuzzy C-means dan Rapid Region Merging untuk Pemisahan Sel Kanker Payudara
Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017 Segmentation and overlapped cells separation are important phases in microscopic image processing of breast cancer, because the accuracy of overlapped cells separation result determines the accuracy of breast cancer cell calculation. The amount of breast
Desmin Tuwohingide, Chastine Fatichah
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Desmin Modulates Muscle Cell Adhesion and Migration
Frontiers in Cell and Developmental Biology, 2022 Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator.
Coralie Hakibilen +16 more
doaj +1 more source