Results 51 to 60 of about 38,385 (299)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Towards a mental probability logic

open access: yesPsychologica Belgica, 2005
We propose probability logic as an appropriate standard of reference for evaluating human inferences. Probability logical accounts of nonmonotonic reasoning with SYSTEM P, and conditional syllogisms (MODUS PONENS, etc.) are explored.
Niki Pfeifer, Gernot D. Kleiter
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

On linear rewriting systems for Boolean logic and some applications to proof theory [PDF]

open access: yesLogical Methods in Computer Science, 2017
Linear rules have played an increasing role in structural proof theory in recent years. It has been observed that the set of all sound linear inference rules in Boolean logic is already coNP-complete, i.e. that every Boolean tautology can be written as a
Anupam Das, Lutz Straßburger
doaj   +1 more source

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

open access: yesArthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah   +5 more
wiley   +1 more source

Algorithmic construction of explicit numerical schemes and visualization of objects and processes in the computational experiment in fluid mechanics [PDF]

open access: yesКомпьютерные исследования и моделирование, 2015
The paper discusses the design and verification stages in the development of complex numerical algorithms to create direct computational experiments in fluid mechanics.
A. B. Degtyarev   +2 more
doaj   +1 more source

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez   +12 more
wiley   +1 more source

Interaction between Molten Al‐Killed Mn–B Steel and Carbon‐Bonded MgO Refractories Based on Recyclates

open access: yesAdvanced Engineering Materials, EarlyView.
High‐temperature interactions between low‐sulfur Al‐killed Mn–B steel and MgO–C refractories (0 and 50 wt% recyclates) are studied via finger immersion tests (1600 °C). Surface‐active elements influence infiltration. MgO/CaS layer forms, along with spinel and calcium silicate.
Matheus Roberto Bellé   +5 more
wiley   +1 more source

The Effects of the Underground Economy on Demand for Imports of Intermediate, Consumption and Capital Goods in Iran [PDF]

open access: yesپژوهشهای اقتصادی, 2016
This paper investigates the effects of underground economy on the Iran’s imports demand for intermediate, consumption and capital goods during 1971-2011.
hamidReza horry   +2 more
doaj  

Developing a Performance Measurement Framework and Indicators for Community Health Service Facilities in Urban China

open access: yesBMC Family Practice, 2010
Background China has had no effective and systematic information system to provide guidance for strengthening PHC (Primary Health Care) or account to citizens on progress.
Wang Bin   +5 more
doaj   +1 more source

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