Results 91 to 100 of about 279,479 (299)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Model Driven Reverse Engineering Framework for Generating High Level UML Models From Java Source Code

IEEE Access, 2019
Legacy systems are large applications which are significant in performing daily organizational operations and cannot be upgraded easily especially in the absence of architectural and design documentation.
Umair Sabir, Farooque Azam, Sami Ul Haq, Muhammad Waseem Anwar, Wasi Haider Butt, Anam Amjad   +5 more
doaj   +1 more source

Traumatic Brain Injury Rehabilitation Intermediate Representation

, 2013
Traumatic Brain Injury Rehabilitation "Intermediate Representation" developed in Michael Grove, PhD dissertation (September, 2013). This is an artifact which informed the subsequent development of the TBI rehabilitation ontology also archived in the ...
Grove, Michael
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Intermediate representations for controllers in chip generators

2011 Design, Automation & Test in Europe, 2011
Creating parameterized “chip generators” has been proposed as one way to decrease chip NRE costs. While many approaches are available for creating or generating flexible data path elements, the design of flexible controllers is more problematic. The most common approach is to create a microcoded engine as the controller, which offers flexibility ...
Kyle Kelley, Megan Wachs, Andrew Danowitz, P. Stevenson, Stephen Richardson, Mark Horowitz   +5 more
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Pegasus: An Efficient Intermediate Representation

, 2002
We present Pegasus, a compact and expressive intermediate representation for imperative languages. The representation is suitable for target architectures supporting predicated execution and aggressive speculation. In Pegasus information about the global
Seth Copen Goldstein, Mihai Budiu
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Exploring Dynamic Hierarchical Fusion for Multi-View Clustering

IEEE Access
Multi-view clustering is effective at uncovering the latent structures within different views or modalities. However, existing approaches often oversimplify the problem by treating the contribution and granularity of information from all views as uniform,
Zhenshan Chen, Xuran Tian, Lizhen Gao, Gengbin Liao, Yang Shen, Kainan Zheng, Jianglin Fang   +6 more
doaj   +1 more source