Results 91 to 100 of about 269,201 (258)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Speech Watermarking with Discrete Intermediate Representations

Proceedings of the AAAI Conference on Artificial Intelligence
Speech watermarking techniques can proactively mitigate the potential harmful consequences of instant voice cloning techniques. These techniques involve the insertion of signals into speech that are imperceptible to humans but can be detected by algorithms. Previous approaches typically embed watermark messages into continuous space.
Shengpeng Ji, Ziyue Jiang 0001, Jialong Zuo, Minghui Fang 0002, Yifu Chen, Tao Jin 0004, Zhou Zhao 0001   +6 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

GeoIR-Compiler: A Geospatial Intermediate Representation and Compilation Framework for Chinese Urban Spatial Question Answering

ISPRS International Journal of Geo-Information
Natural-language access to spatial databases requires relation interpretation, entity grounding, metric normalization, and database-specific execution semantics.
Chaolin Zhang, Jiqiu Deng, Hui Zhang, Longbo Li, Liji Sun, Xiao Ma   +5 more
doaj   +1 more source

HUGR: A Quantum-Classical Intermediate Representation

CoRR
8 pages, extended abstract submitted to ...
Mark Koch, Agustín Borgna, Seyon Sivarajah, Alan Lawrence, Alec Edgington, Douglas Wilson, Craig Roy, Luca Mondada, Lukas Heidemann, Ross Duncan   +9 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Design of an intermediate representation for query languages

CoRR, 2016
Data oriented applications, usually written in a high-level, general-purpose programming language (such as Java) interact with database through a coarse interface. Informally, the text of a query is built on the application side (either via plain string concatenation or through an abstract notion of statement) and shipped to the database over the wire ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the Effectiveness of Automatic Code Generation for Synthetic Dataset Creation

IEEE Access
This paper compares synthetic and real-world code datasets for machine learning applications in cybersecurity by examining the relationships between machine code and Low-Level Virtual Machine Intermediate Representation (LLVM IR).
Josh Mitchell, Varghese Mathew Vaidyan, Yong Wang   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source