Results 71 to 80 of about 522,439 (294)

Digital Financial Knowledge Scale (DFKS): Insights from a Developing Economy

International Journal of Financial Studies
This work aims to create and validate the digital financial knowledge scale (DFKS). Three studies were carried out, including a focus group, expert validation, pre-testing, and the application of item response theory.
Kelmara Mendes Vieira, Taiane Keila Matheis, Eliete dos Reis Lehnhart, Fernando Oliveira Tavares   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

D5.3: HEIR Integrated framework intermediate version

, 2022
This deliverable provides a conceptual specification of the HEIR framework architecture and deployment. It presents the current status of the implementation of the HEIR modules grouped into three architecture layers, namely, the Technology Facilitators layer, the Core Framework layer, and the Visualization layer.
Tsakirakis, George, Rodosthenous, Panagiotis, Dimakopoulos, Nikos, Gavrilut, Dragos, Prelipcean, Bogdan, Ilie, Iulia, Alexopoulos, Andreas, Kalipollitis, Leonidas, Smyrlis, Michail, Khabbaz, Marwan   +9 more
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

RATIO OF FORMAL AND LEXICAL-SEMANTIC VARIATION OF THE WORD IN THE LANGUAGE SYSTEM

Вестник Кемеровского государственного университета, 2013
The question of the saturation of lexical structure of language system with formal and lexical-semantic versions of the word is considered, similarity of external (material) and internal (ideal) variations of the word comes to light on an extensive ...
Z. M. Bogoslovskaya
doaj  

Modeling capsid self-assembly: Design and analysis

, 2010
A series of simulations aimed at elucidating the self-assembly dynamics of spherical virus capsids is described. This little-understood phenomenon is a fascinating example of the complex processes that occur in the simplest of organisms.
Rapaport, D. C.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Intermediate Data Structure (IDS) for Longitudinal Historical Microdata, version 4

Historical Life Course Studies, 2014
The Intermediate Data Structure (IDS) is a standard data format that has been adopted by several large longitudinal databases on historical populations.
George Alter, Kees Mandemakers
doaj   +1 more source