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Pharmacotherapy of intermittent claudication
Expert Opinion on Pharmacotherapy, 2001Intermittent claudication (IC) is leg muscle pain, cramping and fatigue brought on by exercise and is the primary symptom of peripheral arterial disease. The goals of pharmacotherapy for IC are to increase the walking capacity/quality of life and to decrease rates of amputation.
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Management of intermittent claudication
Cardiology Clinics, 2002Medical management of PAD is a considerable challenge. Although patients typically present with IC, there is a substantial pool of subclinical PAD patients. PAD, whether symptomatic or not, confers a marked cardiovascular risk; with affected patients dying of heart attack or stroke, identification of index patients and aggressive medical treatment can ...
Robert D, Brook +3 more
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Pentoxifylline for intermittent claudication
2005Intermittent claudication (IC) is a symptom of peripheral arterial occlusive disease (PAD). It is associated with high morbidity and mortality. Pentoxifylline is one of many drugs used to treat IC. Pentoxifylline decreases blood viscosity, improves erythrocyte flexibility, and increases microcirculatory flow and tissue oxygen concentration.Many studies
Kareem, Salhiyyah +4 more
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Archives of Surgery, 1974
A study was made of 162 persons with intermittent claudication who were observed for an average of 8.3 years. These were all the cases that evolved from a population cohort during 18 years of follow-up. They were essentially untreated until rest pain and tissue loss began. Only four progressed to major amputations and three to toe loss.
C N, Peabody, W B, Kannel, P M, McNamara
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A study was made of 162 persons with intermittent claudication who were observed for an average of 8.3 years. These were all the cases that evolved from a population cohort during 18 years of follow-up. They were essentially untreated until rest pain and tissue loss began. Only four progressed to major amputations and three to toe loss.
C N, Peabody, W B, Kannel, P M, McNamara
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Intermittent claudication in athletes
The Journal of Sports Medicine, 1975All reported cases have occurred in the anterior tibial or rarely peroneal compartments. Case I and V in this series follow this same pattern. Case II and III are unusual in that they are the first recorded cases of this syndrome occuring in the calf of a leg.
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Pentoxifylline and Intermittent Claudication
Annals of Internal Medicine, 1985Excerpt The Food and Drug Administration has recently approved the use of pentoxifylline, a methylxanthine with vasoactive properties (1), for the symptomatic treatment of intermittent claudication...
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Prostanoids for intermittent claudication
2003Peripheral arterial occlusive disease (PAOD) is a common cause of morbidity in the general population. While numerous studies have established the efficacy of prostanoids in PAOD stages III and IV the question of the role of prostanoids as an alternative or additive treatment in patients suffering from claudicatio intermittens (PAOD II) has not yet ...
M, Reiter +3 more
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Drugs, 1987
The mainstay of treatment for claudication is reversal of risk factors, especially smoking, and the use of antiplatelet drugs and possibly pentoxifylline. A major factor in the long term management is atherosclerotic involvement in other parts of the circulation resulting in a shortened life span. Treatment should be directed at the disease in general,
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The mainstay of treatment for claudication is reversal of risk factors, especially smoking, and the use of antiplatelet drugs and possibly pentoxifylline. A major factor in the long term management is atherosclerotic involvement in other parts of the circulation resulting in a shortened life span. Treatment should be directed at the disease in general,
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Intermittent Claudication — Be Conservative
New England Journal of Medicine, 1991Severe peripheral vascular disease is a common disorder that frequently creates substantial morbidity in our aging population.
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