Results 31 to 40 of about 1,954,300 (257)

Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces

open access: yesBioengineering
Docetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high blood toxicity restrict its clinical application.
Hao Wang   +9 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Reconstructing the intrinsic potential energy landscape of interfacial interactions with thermally modulated force spectroscopy

open access: yesPhysical Review Research, 2021
Force probes are powerful experimental tools to measure the strength and physical extent of interfacial and intermolecular interactions at nanometer scales.
Alan Y. Liu, Todd A. Sulchek
doaj   +1 more source

A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation

open access: yesLife, 2021
How proteins properly fold and maintain solubility at the risk of misfolding and aggregation in the cellular environments still remains largely unknown.
Seong Il Choi, Baik L. Seong
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

open access: yesFEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Intermolecular Force Field Parameters Optimization for Computer Simulations of CH4 in ZIF-8

open access: yesJournal of Nanotechnology, 2016
The differential evolution (DE) algorithm is applied for obtaining the optimized intermolecular interaction parameters between CH4 and 2-methylimidazolate ([C4N2H5]−) using quantum binding energies of CH4-[C4N2H5]− complexes.
Phannika Kanthima   +2 more
doaj   +1 more source

Particle Entrapment in Line Elastohydrodynamic Contacts and the Influence of Intermolecular (van der Waals) Forces

open access: yesLubricants, 2020
A metallic particle passing through concentrated rolling-sliding contacts is often linked to surface damage for particles larger than the available gap. At the instant of particle pinching, force balancing dictates particle entrapment and passing through
George K. Nikas
doaj   +1 more source

Perturbation theories of weak intermolecular forces [PDF]

open access: yes, 1969
Exchange perturbation theories of weak intermolecular ...
Certain, P. R.
core  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

Modeling of the intermolecular Force-Induced Adhesion in Freestanding Nanostructures Made of Nano-beams

open access: yesJournal of Applied and Computational Mechanics, 2015
Among the intermolecular interactions, the Casimir and van der Waals forces are the most important forces that highly affect the behavior of nanostructures.
Alireza Yekrangi, Rahman Soroush
doaj   +1 more source

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