Results 51 to 60 of about 3,923,028 (345)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Quantum Internal Model Principle: Decoherence Control
, 2007 In this article, we study the problem of designing a Decoherence Control for quantum systems with the help of a scalable ancillary quantum control and techniques from geometric control theory, in order to successfully and completely decouple an open ...
Ganesan, Narayan, Tarn, Tzyh-Jong
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Creation of Internal Control Tools to Address Emerging Challenges of the External Environment
Учёт. Анализ. АудитToday domestic entities operate under the conditions of environmental challenges significant influence, which are predominantly negative and unpredictable.
T. E. Tatarovskaya
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The structure of optimism : "Controllability affects the extent to which efficacy beliefs shape outcome expectancies" [PDF]
, 2012 In this article we theoretically develop and empirically test an integrative conceptual framework linking dispositional optimism as general outcome expectancy to general efficacy beliefs about internal (self) and external (instrumental social support and
Monsen, Erik, Urbig, Diemo
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Impact of Internal Control System on External Audit Fee Determination in Nigeria [PDF]
, 2009 This stud.v is pmlllfll!'d /Jy tt desire to .find out the impact qf' internal control system on external audit fee determination, based on the experience in Nigeria.
Emeni, F. K.
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