Results 31 to 40 of about 412,743 (259)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Comparative Economic Research, 2020 Along with the development of economies based on knowledge, the importance of knowledge input in production processes has been increasing. Enterprises may acquire knowledge input by developing their internal knowledge base and/or purchasing knowledge ...
Joanna Wyszkowska-Kuna
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The Productivity Effects of Internal and External R&D: Evidence From a Dynamic Panel Data Model [PDF]
We examine the impact of internal and external R&D on labor productivity in a 6-year panel of Dutch manufacturing firms. We apply a dynamic linear panel data model that allows for decreasing or increasing returns to scale in internal and external R&D and
Carree, Martin +2 more
core +2 more sources
Innovative activity sources and its relation with theinnovative performance
Management Letters/Cuadernos de Gestión, 2013 The paper studies the effect of innovative activities sources on innovation performance. For the empirical study we use data from the Encuesta sobre Innovación Tecnológica de las Empresas for the year 2007.
Gema García Piqueres +2 more
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SOURCES THAT MANAGERS PREFER FOR BUSINESS INFORMATION NEEDS
Mehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2019 This study aims to reveal how business managersassociate their information needs and the information sources to meet theseneeds. In order to answer this question, face-to-face interviews were carriedout with a total of 327 business managers working in ...
Çiğdem Baskıcı
doaj +1 more source
Extended Carbon Emission Pinch Analysis for the Low-Carbon Tobacco Industry
Energies, 2022 The tobacco industry is an important contributor to realizing the carbon reduction goal. Less attention is paid to the carbon emissions of the tobacco industry.
Yang Zhang +4 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Analysis and simulations of a frequency synthesizer with internal and external noise sources [PDF]
Advances in Radio Science, 2006 In this paper, a novel technique to analyse the noise behaviour of a second-order-PLL based synthesizer is demonstrated. Its non-linear behaviour is analyzed with independent noise-sources introduced at different points of the circuit.
G. S. Sangha, M. H. W. Hoffmann
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