Results 41 to 50 of about 7,216,063 (252)

The role of external involvement in the creation of management innovations [PDF]

, 2014
There has recently been renewed scholarly interest in management innovating, the creation of new organizational practices, structures, processes and techniques. We suggest that external involvement in the process of management innovating can transpire in
Michael J. Mol, Mol, Michael J., Birkinshaw, J., Birkinshaw, J, Julian Birkinshaw, Mol, M, Birkinshaw, Julian, Mol, Machiel   +7 more
core   +1 more source

The Productivity Effects of Internal and External R&D: Evidence From a Dynamic Panel Data Model [PDF]

We examine the impact of internal and external R&D on labor productivity in a 6-year panel of Dutch manufacturing firms. We apply a dynamic linear panel data model that allows for decreasing or increasing returns to scale in internal and external R&D and
Carree, Martin, Lokshin, Boris, Belderbos, René   +2 more
core   +2 more sources

The innovation paradox: the role of knowledge heterogeneity in frugal innovation

Cogent Business & Management
With the worsening environmental crisis and the rapid advancement of Industry 4.0, more enterprises are recognizing the importance of sustainable development, yet practical challenges remain.
Jingwu Chen, Fan Zhang
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Learning from openness : the dynamics of breadth in external innovation linkages [PDF]

, 2014
We explore how openness in terms of external linkages generates learning effects, which enable firms to generate more innovation outputs from any given breadth of external linkages.
Love, James H., Roper, Stephen, Vahter, Priit   +2 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The external and internal context [PDF]

, 2014
The practice of designing, delivering and evaluating learning and development occurs primarily in organisational contexts. It is therefore necessary for practitioners to have an understanding of factors influencing those contexts.
Mills, Sophie, Sidhu, Dalbir, Lee, Amanda, Sidhu, D.   +3 more
core  

Subsidiary innovation performance:Balancing external knowledge sources and internal embeddedness [PDF]

, 2020
The open innovation (OI) literature has focused primarily on OI strategies and external sourcing of knowledge at the organizational level and has paid less attention to the role of subsidiaries in the OI activities of multinational corporations (MNCs ...
Bresciani, Stefano, Bogers, Marcel L.A.M., Ferraris, A., Ferraris, Alberto, Brescianini, Sonia, Bresciani, S., Bogers, M. L. A. M.   +6 more
core   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source