Results 41 to 50 of about 1,833,432 (178)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

دور الضغوط الوظيفية الداخلية على أداء العاملين دراسة ميدانية على تجميع السيارات فى جمهورية مصر العربية [PDF]

open access: yesمجلة العلوم الادارية والسياسية
يهدف هذا البحث إلى دراسة دور الضغوط الوظيفية الداخلية على أداء العاملين وذلك دراسة ميدانية على تجميع السيارات فى جمهورية مصر العربية.يهدف هذا البحث بشكل أساسي إلى تقديم إطار يدرس دور التسويق الداخلى على تنمية القدرة التنافسية للشركات بالتطبيق علي مجال ...
محمد امين عبدالغنى مخيمر
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Treatment of intertrochanteric fractures of the femur with Ender nails in patients over the age of 65 years

open access: yesActa Orthopaedica et Traumatologica Turcica, 2021
Objectives: We evaluated the results of treatment with Ender nails in intertrochanteric fractures of the femur in patients exceeding the age of 65 years.
Osman Tugrul Eren   +4 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

PERILAKU AGRESI PADA ANAK USIA DINI

open access: yesAs-Sibyan, 2017
Agresi adalah tingkah laku individu yang ditujukan untuk melukai atau mencelakakan individu lain yang tidak menginginkan datangnya tingkah laku tersebut.
Yahdinil Firda Nadhirah
doaj  

Results of excision of the radial head in comminuted fractures

open access: yesActa Orthopaedica et Traumatologica Turcica, 2021
Objectives: To evaluate the results of radial head excision in the treatment of comminuted radial head fractures. \r\nMethods: The study included 20 patients (14 men, 6 women; mean age 34 years; range 21 to 55 years) who underwent radial head excision ...
Osman Tugrul Eren   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The effect of calcium sulfate on fracture healing in rat tibial fractures

open access: yesActa Orthopaedica et Traumatologica Turcica, 2021
Objectives: Calcium sulfate dihydrate (CSD) has been successfully used as an osteconductive biomaterial for bone defects since the last century. Osteoconductive biomaterials are also known to be useful in fracture healing. In this study the effect of CSD
Nadir Sener   +3 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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