Results 41 to 50 of about 7,451,303 (266)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Africa: from voluntary principles to binding standards [PDF]
Forced Migration Review, 2008 A continent-wide Convention to protect IDPs in Africa couldsoon be adopted by the African Union. If sufficiently robustand aligned closely with the Guiding Principles, it would senda powerful signal about Africa’s determination to addressIDP issues.
Brigitta Jaksa, Jeremy Smith
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
دور الضغوط الوظيفية الداخلية على أداء العاملين دراسة ميدانية على تجميع السيارات فى جمهورية مصر العربية [PDF]
مجلة العلوم الادارية والسياسيةيهدف هذا البحث إلى دراسة دور الضغوط الوظيفية الداخلية على أداء العاملين وذلك دراسة ميدانية على تجميع السيارات فى جمهورية مصر العربية.يهدف هذا البحث بشكل أساسي إلى تقديم إطار يدرس دور التسويق الداخلى على تنمية القدرة التنافسية للشركات بالتطبيق علي مجال ...
محمد امين عبدالغنى مخيمر
doaj +1 more source
Orthopaedic Surgery, 2021 Cannulated screw fixation is widely used in the treatment of femoral neck fractures. During surgery, we often face the situation that a guide wire needs to be adjusted because of poor positioning in the femoral neck.
Yu‐feng Chen +6 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2021 Objectives: We evaluated the results of treatment with Ender nails in intertrochanteric fractures of the femur in patients exceeding the age of 65 years.
Osman Tugrul Eren +4 more
doaj
Left Paraduodenal Hernia: An Uncommon Cause of Acute Abdomen
International Journal of Gerontology, 2011 A 66-year-old woman visited the emergency department because of sudden onset of nausea, vomiting, and left hemi-abdominal pain that progressed to the upper hemi-abdomen 2 hours prior to her visit.
Chia-Lin Chiang +4 more
doaj +1 more source