Results 31 to 40 of about 303,399 (243)

Reply to Horta: Spectrum Arguments, the “Unhelpfulness” of Rejecting Transitivity, and Implications for Moral Realism

open access: yesLaw, Ethics and Philosophy, 2015
This article responds to Oscar Horta’s article “In Defense of the Internal Aspects View: Person-Affecting Reasons, Spectrum Arguments and Inconsistent Intuitions”. I begin by noting various points of agreement with Horta.
Larry Temkin
doaj  

Capturing Dynamics in Business Model Frameworks

open access: yesJournal of Open Innovation: Technology, Market and Complexity, 2019
Business model dynamics is important, because high-tech companies, the technology that they commercialize, and the market in which they operate all change over time.
Hanieh Khodaei, Roland Ortt
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Internal or External Grounds for the Nontransitivity of “Better/Worse than”

open access: yesLaw, Ethics and Philosophy, 2015
In his book Rethinking the Good: Moral Ideals and the Nature of Practical Reasoning Larry Temkin contrasts two views of ideals for evaluating outcomes: the Internal Aspects View and the Essentially Comparative View.
Ingmar Persson
doaj  

The Role of Interactive Technologies, Virtual Reality and Artificial Intelligence in Teaching Propaedeutics of Internal Diseases: Perspectives from Teachers and Students

open access: yesJuvenis Scientia
The present review is a critical view of the teachers of the Department of Propaedeutics of Internal Diseases and students on the current problems of teaching clinical disciplines, in particular, the development of practical skills. Objective reasons and
Timofeev, E.V.   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Oficiales de la pluma y prácticas documentales en la Casa de la Contratación de Indias: su significación como instrumentos de gobierno

open access: yesNuevo mundo - Mundos Nuevos, 2017
The aim of this paper is to show an innovative view on the House of Trade as an organism producing documents for the government of America. One of the least known aspects of this institution is its internal functioning relating to the management and ...
Francisco Fernández-López
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Management and Evaluation of Monitoring in the Internal Audit Sector of a Brazilian Federal University: A Constructive Proposal

open access: yesRevista Iberoamericana sobre Calidad, Eficacia y Cambio en Educación, 2018
The internal audit must contribute with the administration through the orientation of the best practices, as well as through the evaluation of organizational performance to improve the management and moving away from the mere narrative of control ...
Lucas dos Santos Matos   +2 more
doaj   +1 more source

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