Results 41 to 50 of about 2,365,141 (284)
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Rethinking the Good – A Small Taste
Law, Ethics and Philosophy, 2015 This article aims to convey a few of the key claims and arguments of my book, Rethinking the Good: Moral Ideals and the Nature of Practical Reasoning. The article gives an example of a Spectrum Argument, and illustrates that such arguments put pressure ...
Larry Temkin
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Towards a new European Global Security Strategy: challenges and Opportunities [PDF]
, 2015 This report briefly examines the interplay between the European security strategic vision and capabilities, its institutional architecture and policy implementation practices, with a particular focus on the EU consular affairs, EU democracy promotion and
Korosteleva, Elena +3 more
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Law, Ethics and Philosophy, 2015 This article responds to Oscar Horta’s article “In Defense of the Internal Aspects View: Person-Affecting Reasons, Spectrum Arguments and Inconsistent Intuitions”. I begin by noting various points of agreement with Horta.
Larry Temkin
doaj
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Internal or External Grounds for the Nontransitivity of “Better/Worse than”
Law, Ethics and Philosophy, 2015 In his book Rethinking the Good: Moral Ideals and the Nature of Practical Reasoning Larry Temkin contrasts two views of ideals for evaluating outcomes: the Internal Aspects View and the Essentially Comparative View.
Ingmar Persson
doaj
Juvenis ScientiaThe present review is a critical view of the teachers of the Department of Propaedeutics of Internal Diseases and students on the current problems of teaching clinical disciplines, in particular, the development of practical skills. Objective reasons and
Timofeev, E.V. +4 more
doaj +1 more source
Capturing Dynamics in Business Model Frameworks
Journal of Open Innovation: Technology, Market and Complexity, 2019 Business model dynamics is important, because high-tech companies, the technology that they commercialize, and the market in which they operate all change over time.
Hanieh Khodaei, Roland Ortt
doaj +1 more source