Results 61 to 70 of about 2,362,923 (282)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The triggering factor of the origin of language. Stories come first, replies to Arbib, Benítez-Burraco, Delfitto, Romano, and Sibierska & Wacewicz

Rivista Internazionale di Filosofia e Psicologia
This article responds to the comments and criticisms raised in relation to my previous work “Stories come first. The origins of human communication from a naturalized perspective of language”.
Francesco Ferretti
doaj   +1 more source

Management and Evaluation of Monitoring in the Internal Audit Sector of a Brazilian Federal University: A Constructive Proposal

Revista Iberoamericana sobre Calidad, Eficacia y Cambio en Educación, 2018
The internal audit must contribute with the administration through the orientation of the best practices, as well as through the evaluation of organizational performance to improve the management and moving away from the mere narrative of control ...
Lucas dos Santos Matos, Sandra Mara Iesbik Valmorbida, Sandra Rolim Ensslin   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Research and the Christian identity of universities

Church, Communication and Culture
In order to explore the relationship between research and universities with a Christian identity, it is important to be clear about the identity of social realities and the meaning of ‘Christian identity’ when applied to universities.
Ana Marta González
doaj   +1 more source

Structure development and simulation of plug-in hybrid electric vehicle [PDF]

, 2013
Electric-drive vehicles (EDVs) have gained attention, especially in the context of growing concerns about global warming and energy security aspects associated with road transport.
Marozka, Aleh, Petrenko, Y. N.
core  

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

An integrated solution from the islamic mysticism to the problems stated by the averroist theory of the «intellect in potency»

Pensamiento. Revista de Investigación e Información Filosófica, 2013
The present article shows the internal consistency of the tasāwwaf iŝrāqiʼs theory of images, with the outstanding Averroist’s theory of the intellect in potency.
Carlos I. Medina Labayru
doaj  

Evaluation of the Workplace Environment in the UK, and the Impact on Users’ Levels of Stimulation [PDF]

, 2013
The purpose of this study is to evaluate a number of recently completed workplaces in the UK. The first aim is to assess the impact of various aspects of the workplace environment on users’ levels of stimulation.
Abdou HG, Baron RA, BCO, Bell A, Birren F, Brill M, Bromley AKR, Chiles WD, CIBSE, CIBSE, CIBSE, CIBSE, Cohen R, Colquhoun WP, Davis MC, de Dear RJ, Duffy F, Egan D, Fanger PO, Folkard S, Grossauer E, Heerwagen JH, Helander MG, Hildebrandt G, Kaplan R, Kroemer KHE, McKeown C, Newsham G, Oseland N, Oseland NA, Preiser WFE, Roscoe JT, Rose M, Russell Bernard H, Sacre P, Sharland I, Vernon MD, Wright A   +37 more
core   +1 more source