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An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin +10 more
wiley +1 more source

Appropriate Use and Reporting of AI tools in Manuscript Preparation. [PDF]

Saudi J Med Med Sci
Al-Quorain AA, Shaikh AK, Abdul Salam A.
europepmc +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie +17 more
wiley +1 more source

Compliance with Clinical Guidelines and AI-Based Clinical Decision Support Systems: Implications for Ethics and Trust. [PDF]

Sci Eng Ethics
Pardoux É, Kerasidou A.
europepmc +1 more source

The COVID-19 pandemic in the hotel industry: the application of hygiene and safety protocols by hotel employees. [PDF]

Rev Inst Med Trop Sao Paulo
Butuhy CRRS, Luna EJA.
europepmc +1 more source

Measuring emotion dysregulation in pregnancy using smartphone activity: a prospective research study in the United States. [PDF]

BMC Pregnancy Childbirth
Henry RD.
europepmc +1 more source

Psychometric Evaluation of the Impulsive-Compulsive Behaviours Checklist (ICB) in a Spanish Prison Population. [PDF]