Results 231 to 240 of about 739,581 (296)

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Reply: Reassessing pre-existing comorbidity patterns in testicular cancer: controversies and future directions. [PDF]

Hum Reprod Open
Ornstrup MJ, Berglund A, Agerbæk M, Gravholt CH.   +3 more
europepmc   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Unruptured Giant Internal Carotid Artery Aneurysm Compressing the Pituitary Gland Leading to Panhypopituitarism. [PDF]

AACE Endocrinol Diabetes
Sharma S, Acharya M, Bean S, Manoochehri S, Singh V.   +4 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

MRI-based assessment of posterior condylar cartilage defects and their impact on femoral component rotational alignment in osteoarthritic knees. [PDF]

J Orthop Surg Res
Polat Y, Keçeci T.
europepmc   +1 more source

Generating Findings for Jaw Cysts in Dental Panoramic Radiographs Using a GPT-Based VLM: A Preliminary Study on Building a Two-Stage Self-Correction Loop with a Structured Output (SLSO) Framework. [PDF]

Diagnostics (Basel)
Hosokawa N, Takahashi R, Kitano T, Iida Y, Muramatsu C, Hayashi T, Seino Y, Zhou X, Hara T, Katsumata A, Fujita H.   +10 more
europepmc   +1 more source

Key challenges in nurse-led foot care education for persons with diabetes: an international survey across six countries. [PDF]

BMC Nurs
Liu Y, Riklikiene O, Ezenwaka C, Nwankwo CU, Zhu S, Makhanbetkulova D, Analike RA, Bulikaite V, Dabyl A, Fan X, Victor V, Zhang Q, Takeno Y.   +12 more
europepmc   +1 more source

Lower limb injuries and concussions dominate in collegiate women's ice hockey: a systematic review and meta-analysis. [PDF]

BMJ Open Sport Exerc Med
Laaksonen J, Pakarinen O, Vaajala M, Liukkonen R, Kuitunen I.   +4 more
europepmc   +1 more source

AI in the Classroom: Observing Preclinical Students' Use of ChatGPT During Case-Based Learning at a UK Medical School. [PDF]

Clin Teach
Taylor AWR, Patel FY, Smyth EK, Gay S, Bird T.   +4 more
europepmc   +1 more source