Results 111 to 120 of about 1,789,974 (346)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Internal Consistency of Academic Scores as an Index of the Validity of Course Exams: a study in Faculty of Pharmacy Kerman University of Medical Sciences [PDF]
Strides in Development of Medical Education, 2012 Background & Objectives: In order to improve the quality of teaching attention to the students academic progress is important In the present study the internal consistency of students scores has been used as an index for the evaluation of the validity of
Ashraf Adhami +4 more
doaj
The Sleep Condition Indicator: a clinical screening tool to evaluate insomnia disorder [PDF]
, 2014 Objective: Describe the development and psychometric validation of a brief scale (the Sleep Condition Indicator (SCI)) to evaluate insomnia disorder in everyday clinical practice.<p></p> Design: The SCI was evaluated across five study ...
Cape, John +5 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Choice, internal consistency, and rationality [PDF]
The classical theory of rational choice is built on several important internal consistency conditions. In recent years, the reasonableness of those internal consistency conditions has been questioned and criticized, and several responses to accommodate ...
Aditi Bhattacharyya +2 more
core
Internal Consistency and Reliability of the Networked Minds\ud Measure of Social Presence [PDF]
, 2004 This study sought to develop and test a measure\ud of social presence. Based on review of current\ud definitions and measures, a synthesis of the\ud theoretical construct that meets the criteria and\ud dimensions [1] is proposed for a broad successful ...
Biocca, Professor Frank +1 more
core
A-10 MoCA-22: Internal Consistency and Convergent Validity of The MoCA’s Auditory Items [PDF]
, 2022 Atash Sabet +2 more
openalex +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
INTERNAL CONSISTENCY IN MODELS OF OPTIMAL RESOURCE USE UNDER UNCERTAINTY [PDF]
For several decades, economists have been concerned with the problem of optimal resource use under uncertainty. In many studies, researchers assume that prices evolve according to an exogenous stochastic process and solve the corresponding dynamic ...
Plantinga, Andrew J., Provencher, Bill
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source