Results 171 to 180 of about 13,572,866 (311)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Pseudo Desired Plant Approach to The Synthesis of Almost Decoupling Control

, 2013
[[abstract]]This paper proposes the pseudo desired plant approach to the almost decoupling control problem. The internal stability of the compensated system is indispensable for most of all control syntheses.
Young, Jieh-Shian; Lin, Yo-Jer; Huang, Yue-Wei
core  

Assessing the Validity of the Fellow Eye as an Internal Control in Early-Phase Clinical Trials for Myopic Chorioretinal Atrophy. [PDF]

J Clin Med
Nagano N, Kanemori E, Hirano Y, Hojo T, Sakaeda Y, Yuguchi T, Kuwayama S, Ogura S, Kimura M, Morita H, Uemura K, Yasukawa T.   +11 more
europepmc   +1 more source

What to Do if the qPCR Test for SARS-CoV-2 or Other Pathogen Lacks Endogenous Internal Control? A Simple Test on Housekeeping Genes. [PDF]

Biomedicines, 2023
Kuzan A, Tabakov I, Madej L, Mucha A, Fulawka L.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Internal and external force-based impedance control for cooperative manipulation

, 2013
An asymptotically stable cascaded control algorithm is proposed for cooperative manipulation of a common object. This algorithm controls motion and internal forces of the object, as well as the contact forces between the object and environment.
Denasi, A., Kostic, D., Nijmeijer, H Henk, Denasi, A Alper, Heck, DJF Dennis, Nijmeijer, H., Heck, D.J.F., Kostic, D Dragan   +7 more
core  

Development of Pentaplex Reverse Transcription Droplet Digital PCR Assay for Simultaneous Detection and Absolute Quantification of HIV-1, HIV-2, HCV, and HBV With Internal Control. [PDF]

Electrophoresis
Lim SY, Koh UN, Kim AL, Kim Y, Kim GE, Lim SK.   +5 more
europepmc   +1 more source

Genome-Wide Screening and Stability Verification of the Robust Internal Control Genes for RT-qPCR in Filamentous Fungi. [PDF]

J Fungi (Basel), 2022
Yang Y, Xu X, Jing Z, Ye J, Li H, Li X, Shi L, Chen M, Wang T, Xie B, Tao Y.   +10 more
europepmc   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Internal Revenue Service annual report.

, 1999
Title from cover.Initial issue covers two fiscal years.Mode of access: Internet.Produced by: Strategic Planning and Communications 1993-1994; by: IRS Communications Division, 1995-Contains statistical tables and organizational information previously ...
United States. Internal Revenue Service., United States. Internal Revenue Service. Communications Division., United States. Internal Revenue Service. Strategic Planning and Communications.   +2 more
core