Results 61 to 70 of about 2,082,908 (266)

THE INTERNAL CONTROL MODELS IN ROMANIA [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
Internal control is indissolubly linked to business and accounting. Throughout history, domestic and international trade has grown exponentially, which has led to an increasing complexity of internal control, to new methods and techniques to control ...
TEODORESCU CRISTIAN DRAGOȘ
doaj  

The impact of COSO control components on internal control effectiveness: An internal audit perspective

open access: yesJournal of Economic and Financial Sciences, 2013
Boards of directors have the ultimate responsibility for governance – including internal control – in their organisations. Management is tasked with the design, implementation and maintenance of internal control systems. Internal auditors play a key role
Houdini Fourie, Christo Ackermann
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Internal financial control and internal audit in budget institutions

open access: yesУченые записки Российской академии предпринимательства, 2021
It is an undeniable fact that the need for continuous improvement in internal auditing and internal financial controls in budgetary institutions is due to the continuous transformation of the Russian Federation's budget model, which requires rational and
I. J. Saifutdinov
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

ERANAN PENGENDALIAN INTERNAL PADA KOPERASI PURLINA KOTA SEMARANG

open access: yesEconomic Education Analysis Journal, 2015
Tujuan penelitian ini untuk menelaah bagaimana peranan pengendalian internal dalam lingkungan, penilaian risiko, aktivitas pengendalian, informasi dan komunikasi, monitoring/pemantauan di Koperasi Purlina Kota Semarang.
Rizky Widya Astari, Ade Rustiana
doaj  

Theoretical grounds of internal audit in the system of state financial control in Ukraine [PDF]

open access: yesProblemi Ekonomiki, 2013
The article considers modern directions of reformation of the system of state financial control connected with introduction of the state internal financial control.
Dikan Larysa V., Kalinkin Dmytro V.
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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