Results 41 to 50 of about 1,289,941 (318)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

From Internal Evaluation toward Quality Assurance in Distance Higher Education of Iran [PDF]

پژوهش در نظام‌های آموزشی, 2011
Iranian higher education (HE) includes two headquarters named Ministry of Science, Research and Technology and Ministry of Health and Medical education; it also contains about 1500 universities and HE institutions. There are presence and distance courses
Reza Mohammadi, Faranak Mokhtarian, Atefeh Saed   +2 more
doaj  

Persistence of potential ST398 MSSA in outpatient settings among US veterans, 2010–2019

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Novel ST398 methicillin susceptible Staphylococcus aureus (MSSA) in the United States was first observed in New York City (2004–2007); its diffusion across the country resulted in changing treatment options.
Margaret Carrel, Qianyi Shi, Shinya Hasegawa, Gosia S. Clore, Michael Z. David, Eli N. Perencevich, Matthew Smith, Michihiko Goto   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The Effect of Outcome Selection on the Performance of Prediction Models in Patients at Risk for Sepsis

Critical Care Explorations, 2020
Importance:. Risk prediction models for patients with suspected sepsis have been derived on and applied to various outcomes, including readily available outcomes such as hospital mortality and ICU admission as well as longer-term mortality outcomes that ...
Stephanie P. Taylor, MD, MS, Shih-Hsiung Chou, PhD, Andrew D. McWilliams, MD, MPH, Mark Russo, MD, Alan C. Heffner, MD, Stephanie Murphy, DO, Susan L. Evans, MD, FACS, FCCM, Whitney Rossman, MS, Marc Kowalkowski, PhD, on behalf of Acute Care Outcomes Research Network (ACORN) Investigators, Ryan Brown, Larry Burke, Shih-Hsiung Chou, Kyle Cunningham, Susan L. Evans, Scott Furney, Michael Gibbs, Alan Heffner, Timothy Hetherington, Daniel Howard, Marc Kowalkowski, Scott Lindblom, Andrea McCall, Lewis McCurdy, Andrew McWilliams, Stephanie Murphy, Alfred Papali, Christopher Polk, Whitney Rossman, Michael Runyon, Mark Russo, Melanie Spencer, Brice Taylor, Stephanie Taylor   +33 more
doaj   +1 more source

Patterns of Digoxin Prescribing for Medicare Beneficiaries in the United States 2013-2019

American Journal of Medicine Open, 2023
Background: Studies show that digoxin use is declining but is still prevalent. Recent data on digoxin prescription and characteristics of digoxin prescribers are unknown, which can help understand its contemporary use. Methods: Using Medicare Part D data
Claudia See, Kevin M. Wheelock, César Caraballo, Rohan Khera, Amarnath Annapureddy, Shiwani Mahajan, Yuan Lu, Harlan M. Krumholz, Karthik Murugiah   +8 more
doaj   +1 more source

Lmod Evaluation Internal Report [PDF]

, 2016
The Technology Investigation Service's Technology Evaluation team conducted an evaluation of the lmod user environment management tool. This internal report summarizes their findings.Submitted by Janet Brown (brown@psc.edu) on 2016-06-30T21:33:41Z No ...
The Technology Investigation Service's Technology Evaluation Team
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source