Results 71 to 80 of about 4,018,197 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Structured, proactive care coordination versus usual care for Improving Morbidity during Post-Acute Care Transitions for Sepsis (IMPACTS): a pragmatic, randomized controlled trial

Trials, 2019
s Background Hospital mortality for patients with sepsis has recently declined, but sepsis survivors still suffer from significant long-term mortality and morbidity.
Marc Kowalkowski, Shih-Hsiung Chou, Andrew McWilliams, Cathryn Lashley, Stephanie Murphy, Whitney Rossman, Alfred Papali, Alan Heffner, Mark Russo, Larry Burke, Michael Gibbs, Stephanie P. Taylor, On behalf of Atrium Health ACORN Investigators   +12 more
doaj   +1 more source

Statin Use and Mortality among Patients Hospitalized with Sepsis: A Retrospective Cohort Study within Southern California, 2008–2018

Critical Care Research and Practice, 2022
Background. Despite early goal-directed therapy, sepsis mortality remains high. Statins exhibit pleiotropic effects. Objective. We sought to compare mortality outcomes among statin users versus nonusers who were hospitalized with sepsis.
Brannen Liang, Su-jau T. Yang, Kenneth K. Wei, Albert S. Yu, Brendan J. Kim, Michael K. Gould, John J. Sim   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Systematic Analysis of Quality of Teaching Surveys [PDF]

All tertiary institutions in Australia use the same Course Evaluation Questionnaire (CEQ) however for the internal evaluation of teaching they use their own surveys.
Carol Johnston, Jenny Lye, Joe Hirschberg, Martin Davies   +3 more
core  

Evaluation of a prototype interface for structured document retrieval [PDF]

, 2003
Document collections often display either internal structure, in the form of the logical arrangement of document components, or external structure, in the form of links between documents.
Dunlop, M.D., Reid, J.
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Learning to become an expert : reinforcement learning and the acquisition of perceptual expertise [PDF]

, 2009
To elucidate the neural mechanisms underlying the development of perceptual expertise, we recorded ERPs while participants performed a categorization task. We found that as participants learned to discriminate computer-generated "blob'' stimuli, feedback
Holroyd, Clay, Krigolson, Olav E., Pierce, Lara J., Tanaka, James W.   +3 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Determinants of Left Ventricular Geometric Alterations and Related Clinical and Metabolic Factors in a General Population

International Journal of Gerontology, 2009
Background: Left ventricular (LV) remodeling has been shown to impart prognostic significance in previous studies. However, the underlying exact mechanisms involved and interactions between LV geometry alterations and age with other clinical and ...
Chuan-Chuan Liu, Chi-In Lo, Chung-Lieh Hung, Hung-Ju Ko, Charles Jia-Yin Hou, Hung-I Yeh, Cheng-Ho Tsai, Shou-Chuan Shih, Ray-E Chang   +8 more
doaj   +1 more source