Results 81 to 90 of about 4,018,197 (309)

Impact of internal bremsstrahlung on the detection of gamma-rays from neutralinos [PDF]

, 2010
We present a detailed study of the effect of internal bremsstrahlung photons in the context of the minimal supersymmetric standard models and their impact on gamma-ray dark matter annihilation searches.
Cannoni, M., Gomez, M. E., Panella, O., Prada, F., Sanchez-Conde, M. A.   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Generating VaR scenarios with product beta distributions [PDF]

, 2018
We propose a Monte Carlo simulation method to generate stress tests by VaR scenarios under Solvency II for dependent risks on the basis of observed data.
Pfeifer, Dietmar, Ragulina, Olena
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Internal evaluation and its roles in improving the quality of technique & engineering training, Case: Department of Technique and Engineering Faculty at Shahed University

آموزش مهندسی ایران, 2012
Internal evaluation is a process in which faculty members of departments make judgments about their own performance and plan to improve their future activities.
Majid Darabi , Faranak Mokhtarian, Mohsen Farmahini Farahani, Korosh Esmaeili   +3 more
doaj   +1 more source

A Farm Level Analysis of the Economic Impact of the MARENA Program in Honduras [PDF]

Impact Evaluation, Propensity Score Matching, Fixed Effects, Internal Rate of Return, Technical Efficiency, Honduras, International Development,
Bravo-Ureta, Boris E., de Almeida, Alexandre, Inestroza, Aaron, Solis, Daniel   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous b1/b2 globin gene deletion) mice

Haematologica, 2015
Intermediate beta-thalassemia has a broad spectrum of sequelae and affected subjects may require occasional blood transfusions over their lifetime to correct anemia.
Monique P. Gelderman, Jin Hyen Baek, Ayla Yalamanoglu, Michele Puglia, Florence Vallelian, Bo Burla, Jaroslav Vostal, Dominik J. Schaer, Paul W. Buehler   +8 more
doaj   +1 more source

Numerical evaluation of multi-loop integrals by sector decomposition

, 2003
In a recent paper we have presented an automated subtraction method for divergent multi-loop/leg integrals in dimensional regularisation which allows for their numerical evaluation, and applied it to diagrams with massless internal lines.
Anastasiou, Anastasiou, Anastasiou, Anastasiou, Bern, Bern, Bern, Bern, Bern, Binoth, Binoth, Binoth, Chetyrkin, Davydychev, Denner, Ferroglia, G. Heinrich, Garland, Garland, Gehrmann, Gehrmann, Ghinculov, Glover, Glover, Heinrich, Hepp, Itzykson, Kawabata, Laporta, Moch, Nakanishi, Passarino, Passarino, Roth, Smirnov, Smirnov, Smirnov, Smirnov, Smirnov, Smirnov, Steinhauser, T. Binoth, Tarasov, Tausk, Tkachov, Tkachov, Zavialov   +46 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source