Results 51 to 60 of about 2,277,571 (305)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Toxic effects of PFOS/PFOA and their internal exposure in Chinese general population

Zhongguo shipin weisheng zazhi, 2022
As widely used synthetic chemicals， perfluorooctane sulfonic acid （PFOS） and perfluorooctanic acid （PFOA） are ubiquitous in the environment and the human body.
HAO Lili, ZHANG Lei, NING Junyu, BAO Huihui   +3 more
doaj   +1 more source

The effect of elevated temperature exposure on the fracture toughness of solid wood and structural wood composites [PDF]

, 2004
This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Springer and can be found at: http://www.springer.com/life+sciences/forestry/journal/226.Fracture toughness of wood and wood ...
H.G. Direen, K. Zhang, R. Wagner, S. Abiteboul, S.M. Selkow   +4 more
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Determination of 12 pesticide metabolites in human urine by liquid chromatography-tandem mass spectrometry

环境与职业医学
BackgroundPesticides like organophosphorus and pyrethroids are extensively utilized, and associated potential human health risks arising from multi-route exposure, including environmental sources and dietary intake, cannot be overlooked. Conducting human
Yujie CHEN, Shuling DENG, Yonglin ZHOU, Hao ZHANG, Hualiang LIU   +4 more
doaj   +1 more source

Air pollution modelling for birth cohorts: a time-space regression model [PDF]

, 2016
To investigate air pollution effects during pregnancy or in the first weeks of life, models are needed that capture both the spatial and temporal variability of air pollution exposures.; We developed a time-space exposure model for ambient NO2 ...
Delgado-Eckert, Edgar, Frey, Urs, Latzin, Philipp, Proietti, Elena, Röösli, Martin, Stern, Georgette, Tsai, Ming-Yi, Vienneau, Danielle   +7 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Environmental Monitoring in Uranium Deposit and Indoor Radon Survey in Settlements Located near Uranium Mining Area, South Kazakhstan

Atmosphere
In the late 1960s, a uranium province was explored in the Shu-Sarysu depression in southern Kazakhstan. These mining operations can lead to potential contamination of the environment and pose health risks to the population.
Meirat Bakhtin, Danara Ibrayeva, Yerlan Kashkinbayev, Moldir Aumalikova, Nursulu Altaeva, Aigerim Tazhedinova, Aigerim Shokabayeva, Polat Kazymbet   +7 more
doaj   +1 more source

Methodological approach to development of dosimetric models of the human skeleton for beta-emitting radionuclides

Радиационная гигиена, 2019
Objective of the study: to develop a skeleton model for assessing red bone marrow dose from osteotropic beta-emitting radionuclides. This article describes the modeling methodology which takes into account the individual variability of the macro- and ...
M. O. Degteva, E. A. Shishkina, E. I. Tolstykh, V. I. Zalyapin, P. A. Sharagin, M. A. Smith, B. A. Napier   +6 more
doaj   +1 more source