Results 51 to 60 of about 516,682 (248)

A Comparative Analysis of the Accuracy of Crown Fabricated from Conventional Wax Patterns and CAD/CAM Technology – Milling and 3D Printing

Journal of Pharmacy and Bioallied Sciences
Background: Digital manufacturing techniques such as milling (subtractive) and 3D printing (additive) are increasingly used in dental restorations. These technologies promise enhanced precision and efficiency compared to traditional methods. However, the
MV Sunil Kumar, Rajesh Kumar, Ravindher Singh Saini, Rajesh Vyas, Sunil Kumar Vaddamanu   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Marginal and Internal Fit of Zirconia Crowns with Varying Yttria Content and Finish Line Configurations: An In Vitro Study

Applied Sciences
Aim: This in vitro study aimed to evaluate the marginal and internal fit of three monolithic CAD/CAM zirconia ceramics with different Y-TZP contents, prepared with chamfer and rounded shoulder finish lines. Methods.
Dilan Gizem Doğan, Ömer Suat Yaluğ
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Systematic Review of the Accuracy of Crowns Designed Using Artificial Intelligence Versus CAD/CAM and Traditional Methods

Medicina
Background and Objectives: Advances in digital dentistry, particularly CAD-CAM, have improved the efficiency and precision of crown design and fabrication.
Mohammed A. Alfaifi
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evaluation of the Accuracy of Intraoral Digital Impression Systems and CAD and CAM Workflows for Fabricating Dental Prostheses

Journal of Pharmacy and Bioallied Sciences
Background: Dental prosthesis manufacturing has undergone a radical change with the introduction of intraoral digital impression technologies and computer-aided design and computer-aided manufacturing (CAD and CAM) processes.
Ojas Anand Gajbhiye, M. Pradeep Reddy, Md. Imran, Nikhita Narayanan, Praveen Gangadharappa, Harisha Dewan   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Quantitative Evaluation of Marginal and Internal Fit of CAD/CAM Ceramic Crown Restorations Obtained by Model Scanner, Intraoral Scanner, and Different CBCT Scans

Applied Sciences
(1) Background: This study aimed to evaluate the marginal and internal fit of ceramic crowns produced by various digital methods using microcomputed tomography (MCT) imaging.
Bora Akat, Ayben Şentürk, Mert Ocak, Mehmet Ali Kılıçarslan, Kaan Orhan, Merve Önder, Fehmi Gönüldaş   +6 more
doaj   +1 more source