Results 41 to 50 of about 514,802 (301)

Nonvascular autologous fibular cortical strut graft with internal fixation in monostotic fibrous dysplasia of femur neck- A case report

Journal of Orthopaedic Reports, 2022
Introduction: Fibrous dysplasia is a non-inheritable congenital disorder characterized by bone-forming expansile fibrous lesions that disrupt normal bone architecture.
Mitali Mokashi, Amit Kumar Yadav, Sangeet Gawhale, Farokh Wadia   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

New Internal Fixation Technique for Transconjunctival Fat Repositioning

Plastic and Reconstructive Surgery, Global Open, 2017
Summary:. To treat tear trough deformities in young patients, transconjunctival orbital fat repositioning has been widely used. Although internal fixation of transposed fat enables more secure and stable fixation than the externalized percutaneous suture
Cheol Ho Chang, MD, Myung Kyu Cha, MD
doaj   +1 more source

Internal Fixation of Femoral Neck Fractures [PDF]

, 2015
__Abstract__ This thesis consists of three parts. Part 1 described aspects of the organization of trauma related trials. Part 2 analyzed the uniformity of current femoral neck fracture treatment and adherence to the Dutch guideline on hip fracture ...
Zielinski, S.M. (Stephanie)
core  

Review article: Risk factors of infection following total knee arthroplasty [PDF]

, 2012
22 PubMed articles in English were identified using the key words: ‘risk factors’, ‘infection’, and ‘primary total knee arthroplasty (TKA)’. The 10 most relevant articles were reviewed. In one study, obesity and diabetes were considered risk factors
Rodríguez Merchán, E. Carlos
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Open reduction internal fixation versus external fixation with limited internal fixation for displaced comminuted closed pilon fractures: A randomised prospective study

Journal of Orthopaedics, Trauma and Rehabilitation, 2018
Background: Pilon fractures involve the dome of the distal tibial articular surface. The optimal treatment for high-energy pilon fractures remains controversial.
Ahmed Rayan, Ahmed Kotb, Elhussein M. Elmoatasem, Shady Samir, Tamer A. EL-Sobky, Ezzat El-Hawi, Mahmoud Mahran   +6 more
doaj   +2 more sources

Antibiotic artificial bone implantation for the treatment of infection after internal fixation of tibial plateau fractures

BMC Musculoskeletal Disorders, 2022
Objective To explore the clinical effect of antibiotic artificial bone (Calcium phosphate) in the treatment of infection after internal fixation of tibial plateau fractures.
Haotian Hua, Lei Zhang, Zairan Guo, Wenlong Zhong, Jiangfei Chen, Jiangang Guo, Yang Zhang, Peijian Tong, Xinwei Wang   +8 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source