Results 61 to 70 of about 6,083,953 (343)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Strategies for surgical approaches in open reduction internal fixation of pilon fractures.

Journal of Orthopaedics and Trauma, 2015
Pilon or tibial plafond fractures usually result from high-energy injuries with rotation and/or axial compression. They occur in an area of relatively poor soft tissue coverage and frequently present a surgical challenge in deciding which incisions will ...
M. Assal, A. Ray, R. Stern
semanticscholar   +1 more source

Long term outcomes of open reduction internal fixation versus external fixation of distal radius fractures: A meta-analysis

, 2019
Distal radius fractures are among the most common fractures encountered in the clinical setting. Of these common fractures, it has been said that up to 60% are intraarticular in nature.
Thomas, Michael, Knight, Matthew, Bindra, Randy, Gouk, Conor, Ng, Shu-Kay   +4 more
core   +1 more source

A comparison of the biomechanical properties of three different lumbar internal fixation methods in the treatment of lumbosacral spinal tuberculosis: finite element analysis

Scientific Reports, 2023
There are various internal fixation methods in treating lumbosacral spinal tuberculosis. The study compared the stability and stress distribution in surrounding tissues/implants, such as discs, endplates and screw-rod internal fixation system, etc.
Jiantao Liu, Xi Gong, Kao Wang, Xingyuan Li, Xiwei Zhang, Jiajun Sun, Yihan Zhu, Yixiang Ai, Jing Ren, Jintao Xiu, Wenchen Ji   +10 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Open reduction internal fixation versus external fixation with limited internal fixation for displaced comminuted closed pilon fractures: A randomised prospective study

Journal of Orthopaedics, Trauma and Rehabilitation, 2018
Background: Pilon fractures involve the dome of the distal tibial articular surface. The optimal treatment for high-energy pilon fractures remains controversial.
Ahmed Rayan, Ahmed Kotb, Elhussein M. Elmoatasem, Shady Samir, Tamer A. EL-Sobky, Ezzat El-Hawi, Mahmoud Mahran   +6 more
doaj   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Conservative management versus open reduction and internal fixation for mid-shaft clavicle fractures in adults - The Clavicle Trial: Study protocol for a multicentre randomized controlled trial [PDF]

, 2011
Background: Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures.
Cobiella Carlos, Francis, A, Lee, M, Umile Giuseppe Longo, Andrea Francis, Drew, S, Tennent Duncan, Steven Corbett, Packham, I, Pearse, Y, Longo, UG, Nicholas Garlick, Philip Michael Ahrens, Crowther, Mark, Richards, Andrew, Tennent, Duncan, Tims Emily, Tims, E, Richards, A, Pearse, Yemi, Francis Andrea, Garlick, Nicholas, Garlick Nicholas, Lee Marcus, Corbett Steven, Andrew Richards, Tennent, D, Yemi Pearse, Banerjee Sughran, Emily Tims, Tims, Emily, Cobiella, C, Drew Steven, Crowther Mark, Longo, Umile Giuseppe, Roberts, C, Barber Julie, Barber, Julie, Roberts Chris, Chambler Andrew, Pearse Yemi, Julie Barber, Packham, Iain, Corbett, Steve, Longo Umile, Marcus Lee, Francis, Andrea, Roberts, Chris, Chambler, A, Garlick, N, Carlos Cobiella, Mark Crowther, Ahrens, PM, Sughran Banerjee, Banerjee, S, Chambler, Andrew, Steven Drew, Barber, J, Iain Packham, Chris Roberts, Ahrens Philip, Corbett, S, Lee, Marcus, Packham Iain, Drew, Steven, Cobiella, Carlos, Crowther, M, Duncan Tennent, Richards Andrew, Andrew Chambler, Ahrens, Philip Michael, Banerjee, Sughran   +71 more
core   +2 more sources