Results 81 to 90 of about 3,254,373 (396)

Orthopaedic surgery [PDF]

, 2005
Over the past fifty years orthopaedic surgery made giant strides forward. It developed from a discipline that dealt primarily with the treatment of fractures, bone infections and tendon transfers and that treated degenerate joints by fusing them to one ...
Grixti, Charles J.
core  

Outcomes of total hip arthroplasty, as a salvage procedure, following failed internal fixation of intracapsular fractures of the femoral neck: a systematic review and meta-analysis. [PDF]

, 2016
AIMS: The optimal management of intracapsular fractures of the femoral neck in independently mobile patients remains open to debate. Successful fixation obviates the limitations of arthroplasty for this group of patients.
Archibeck MJ, Blomfeldt R, Broderick JM, Burns PB, Charnley J, Flugsrud GB, Franzén H, Garden RS, Harris WH, Hunt SM, Katz S, McKinley JC, Mehlhoff T, Moher D, Neander G, Nilsson LT, Nilsson LT, Oztürkmen Y, Schmidt AH, Winemaker M, Yang J, Zhang X   +21 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Dual mobility total hip arthroplasty for salvaging failed internal fixation for neck of femur fractures

Journal of Orthopaedics, Trauma and Rehabilitation, 2020
Internal fixation is commonly used to treat fractures in the hip. However, failure of proximal femoral fracture fixation is common and treated with total hip replacement (THR). The aim of this study is to present our midterm results of dual mobility (DM)
Jatinder Singh Luthra, Suwailim Al Ghannami, Salim Al Habsi, Soubhik Ghosh   +3 more
doaj   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Is removal of the internal fixation after successful intervertebral fusion necessary? A case–control study based on patient-reported quality of life

Journal of Orthopaedic Surgery and Research, 2022
Background Intervertebral fusion and internal fixation are often applied to patients with lumbar spinal disease. Whether to remove the internal fixation after successful fusion remains uncertain, but such a question needs to be explored in light of ...
Shangbo Niu, Dehong Yang, Yangyang Ma, Shengliang Lin, Xuhao Xu   +4 more
doaj   +1 more source

Communicating Study Results to Our Patients: Which Way Is Best? [PDF]

, 2008
Before we are able to communicate evidence and evidence results to patients we must first be familiar with the common ways by which results may be presented to our patients. We describe five approaches (relative risk, risk reduction, odds ratio, absolute
Petrisor, BA, Tornetta III, Paul
core   +4 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biomechanical study of different internal fixation devices for femoral neck fractures: finite element analysis based on different reduction qualities

Frontiers in Bioengineering and Biotechnology
ObjectiveTo compare and analyze the biomechanical advantages and disadvantages of four cannulated screws (4CCS) internal fixation device, biplanar double support screw (BDSF) internal fixation device, and dynamic hip screw (DHS) internal fixation device ...
Zhexi Zhu, Zhexi Zhu, Zhongjian Tang, Zhongjian Tang, Yafei Lu, Yafei Lu, Tao Yang, Tao Yang, Jizhe Lu, Jizhe Lu, Chenglong Pang, Bin Wang   +11 more
doaj   +1 more source