Results 221 to 230 of about 54,492 (290)

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 13, Page 3743-3761, July 2026.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida   +7 more
wiley   +1 more source

Effects of Dapagliflozin on Cardiovascular Outcomes in Patients With Type 2 Diabetes at Risk of Liver Fibrosis

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6142-6150, July 2026.
ABSTRACT Aims The fibrosis‐4 (FIB‐4) score is used to identify risk of advanced liver fibrosis. This post hoc analysis investigated its prognostic value for cardiovascular (CV) outcomes and its relevance to the effects of dapagliflozin. Materials and Methods DECLARE‐TIMI 58 was a randomised, placebo‐controlled phase 3 trial investigating dapagliflozin ...
Jan Oscarsson   +12 more
wiley   +1 more source

Flow‐controlled expiration improves gas exchange in anaesthetised horses undergoing orthopaedic surgery

open access: yesEquine Veterinary Journal, Volume 58, Issue 4, Page 917-924, July 2026.
Abstract Background Flow‐controlled expiration (FLEX) has been shown to significantly enhance oxygenation in horses under laboratory conditions. Objective This study aims to corroborate these findings by evaluating the effects of FLEX on gas exchange in a randomised clinical trial involving a large population of clinical horses undergoing orthopaedic ...
Klaus Hopster   +5 more
wiley   +1 more source

Efficacy and welfare effects of different forms of physical restraint for upper airway endoscopy of horses

open access: yesEquine Veterinary Journal, Volume 58, Issue 4, Page 1103-1115, July 2026.
Abstract Background Physical restraint of horses for veterinary procedures is necessary to allow completion of tasks effectively and without injury to patient or personnel. Objectives To compare physiological effects and behavioural responses to four commonly used restraint techniques for upper respiratory tract (URT) endoscopy in unsedated horses ...
Claire O'Brien   +5 more
wiley   +1 more source

Technologies for equine welfare and performance monitoring under field conditions – Where do we stand?

open access: yesEquine Veterinary Journal, Volume 58, Issue 4, Page 872-888, July 2026.
Abstract The need for comprehensive equine welfare assessments has become particularly evident amid ongoing debates about the social licence to operate in equestrian sports. During exercise, multiple physiological systems, principally the cardiovascular, respiratory, muscular, thermoregulatory, endocrine, and locomotory systems, undergo complex ...
Rhana Mackie Aarts   +3 more
wiley   +1 more source

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