Results 61 to 70 of about 3,450,411 (290)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Technology of Inverted Internal Limi ting Membrane Flap in Surgery of Primary Through Macular Retinal Holes. Literature Review

Oftalʹmologiâ
A review of the literature describes various approaches to peeling the internal limiting membrane of the retina in the surgical treatment of penetrating macular holes.
N. M. Shilov, A. V. Tereschenko, N. N. Yudina, S. V. Novikov, S. Z. Kabuldinova   +4 more
doaj   +1 more source

Membrane structure-dependent limiting flux behavior and membrane selectivity loss during gypsum scaling : implications for pressure-retarded osmosis operation and membrane design

, 2020
Herein, we systematically investigated the influence of membrane structural properties on limiting flux behavior and selectivity loss during gypsum scaling in osmotically driven membrane processes.
Mai, Weiting, She, Qianhong, Cheng, Pak Shing, Liu, Zongwen, Fei, Jingyuan, Shi, Jeffrey   +5 more
core   +1 more source

The Effect of Internal Limiting Membrane Peeling on Anatomical and Visual Outcomes in Patients with Macula-Off Retinal Detachment

Türk Oftalmoloji Dergisi
Objectives: This study aimed to evaluate the anatomical and visual outcomes of internal limiting membrane (ILM) peeling in patients with macula-involving (“macula-off”) retinal detachment treated with silicone oil endotamponade.
Deniz Bağcı, Cumali Değirmenci, Filiz Afrashi   +2 more
doaj   +1 more source

Intraoperative Optical Coherence Tomography in Idiopathic Macular Epiretinal Membrane Surgery

International Journal of General Medicine, 2022
Zi-Qing Mao,1 Hong-Xi Wu,1 Hui-Min Fan,1 Gen Li,2 Zhi-Peng You,1 Yun-Yu Tan1 1Department of Ophthalmology, Affiliated Eye Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2Department of Ophthalmology, Zhangshu People’s ...
Mao ZQ, Wu HX, Fan HM, Li G, You ZP, Tan YY   +5 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Recurrence after Spontaneous Resolution of an Idiopathic Epiretinal Membrane

Case Reports in Ophthalmology, 2011
We report a case of recurrent epiretinal membrane (ERM) after spontaneous resolution of an idiopathic ERM. A 65-year-old female demonstrated a spontaneous improvement in visual acuity from 0.1 to 1.2 in her left eye attributable to spontaneous resolution
Yoshihiko Oono, Sohei Nakamura, Koichi Yoshimura, Ryoji Yamakawa, Tetsuya Takayama   +4 more
doaj   +1 more source