Results 41 to 50 of about 595,725 (260)

Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers

Urology, 2005
The International Consensus Panel on cytology and bladder tumor markers evaluated markers that have the ability to predict tumor recurrence, progression, development of metastases, or response to therapy or patient survival. This article summarizes those findings.
Department of Urology, Kyoto University, Kyoto, Japan ( host institution ), Habuchi, Tomonori, Marberger, Michael, Droller, Michael J., Hemstreet, George P., Grossman, H. Barton, Schalken, Jack A., Schmitz-Dräger, Bernd J., Murphy, William M., Bono, Aldo V., Goebell, Peter, Getzenberg, Robert H., Hautmann, Stefan H., Messing, Edward, Fradet, Yves, Lokeshwar, Vinata B.   +15 more
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Digestibidade e desempenho produtivo em cabritos mestiços ½ Boer x ½ Saanen alimentados com dietas contendo gordura protegida

Semina: Ciências Agrárias, 2015
 Objetivou-se com este trabalho, avaliar a ingestão, os parâmetros de desempenho produtivo, a digestibilidade da matéria seca e dos nutrientes de dietas com concentrações crescentes de energia metabolizável contendo gordura protegida, e a análise ...
Sérgio Mangano de Almeida Santos, Claudete Regina Alcalde, Ana Paula Silva Possamai, Bruna Susan de Labio Molina, Bruna Hygino, Leiliane Cristine de Souza, Ludmila Couto Gomes, Isabella Ribeiro Ferrari   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Generation of a Recombinant Porcine Reproductive and Respiratory Syndrome Virus Stably Expressing Two Marker Genes

Frontiers in Veterinary Science, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) has been used as a gene expression vector in the development of vaccines. Most of these recombinant PRRSV vectors express only a single foreign gene through either an internal insertion in the ...
Hao Wang, Xin Xie, Wei He, Yuxu Wang, Tongwei Ren, Kang Ouyang, Ying Chen, Weijian Huang, Zuzhang Wei   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Speciation Progress: A Case Study on the Bushcricket Poecilimon veluchianus. [PDF]

PLoS ONE, 2015
Different mechanisms such as selection or genetic drift permitted e.g. by geographical isolation can lead to differentiation of populations and could cause subsequent speciation.
Lucienne Eweleit, Klaus Reinhold, Jan Sauer   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source