Results 71 to 80 of about 3,586,946 (292)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus [PDF]
, 2007 Alphavirus-based vector and replicon systems have been extensively used experimentally and are likely to be used in human and animal medicine. Whilst marker genes can be inserted easily under the control of a duplicated subgenomic promoter, these ...
Fazakerley, John K +11 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Cutaneous markers of internal disease.
Canadian family physician Medecin de famille canadien, 2013 Cutaneous markers of internal disease are legion. This article discusses the pigmentary disorders, acanthosis nigricans, pruritus, the xanthomas and problems of photosensitivity, outlining the appropriate procedures to establish a definite diagnosis, and in some cases the management of such patients.
R R, Forsey, P M, Reardon
openaire +1 more source
Promotional Brochure from Marker Tours for “Washington Underground”
, 2023 Washington Underground brochure. Enclosed in an envelope with a promotional letter and several brochures, which include: Marker Tours brochure, Mr. Lincoln’s Washington, John Wilkes Booth Escape Route Tour, The National Road, and Stillridge Herb Farm ...
Marker Tours
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Can eczema be a marker for internal malignancy?
Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora, 2020 Paraneoplastic disorders are a group of uncommon symptoms assumed to occur due to the substances released by the tumour or due to abnormal immune system response in patients with internal malignancy. Some neoplastic diseases may present with various cutaneous manifestations.
Gašić, Ana +3 more
openaire +2 more sources
Inflammatory markers in patients with internal carotid artery stenosis
Archives of Medical Science, 2013 Available reports underline the significance of the inflammatory process in the development, progression and destabilisation of atherosclerotic plaques in the internal carotid artery (ICA). The aim of this study was to evaluate the relationship between the degree of ICA stenosis, ultrasound plaque morphology and serum concentration of selected ...
Przemysław Puz +4 more
openaire +2 more sources