Results 31 to 40 of about 4,693,266 (254)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul   +13 more
wiley   +1 more source

Political Processes in Mongolia and the Current Mongolian-Chinese Relationss

open access: yesVestnik MGIMO-Universiteta, 2012
This article provides for an analysis a number of internal political factors in Mongolia that may influence to the current Mongolian-Chinese relations. Among these factors possible to note the balance of political powers, media influence, NGOs, economic ...
G. T. Dambiev
doaj   +1 more source

On the Normal Force and Static Friction Acting on a Rolling Ball Actuated by Internal Point Masses

open access: yes, 2019
The goal of this paper is to investigate the normal and tangential forces acting at the point of contact between a horizontal surface and a rolling ball actuated by internal point masses moving in the ball's frame of reference.
Putkaradze, Vakhtang, Rogers, Stuart
core   +1 more source

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego   +10 more
wiley   +1 more source

ABJM θ-Bremsstrahlung at four loops and beyond

open access: yesJournal of High Energy Physics, 2017
In ABJ(M) theory a generalized cusp can be constructed out of the 1/6-BPS Wilson line by introducing an angle φ in the spacial contour and/or an angle θ in the internal R-symmetry space.
Marco S. Bianchi, Andrea Mauri
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

FACTORS AFFECTING STUDENTS’ CONFIDENCE IN PUBLIC SPEAKING

open access: yesJournal of Languages and Language Teaching, 2018
The researcher aimed to find out an internal and external factors that affected students’ confidence in public speaking performance. The kind of this research was qualitative, this study is dealing with Miles and Huberman theory, the sample of this ...
Muhammad Arif Pratama
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Research on management capacity components of heads of territorial bodies of the Ministry of Internal Affairs of Russia

open access: yesПсихология и право, 2020
The key objective of the Ministry of Internal Affairs of the Russian Federation is law enforcement within the country. Therefore, studying the problems of improving the professional development of managerial personnel in the system of the Ministry of ...
Burtsev A.O., Dashko M.N., Efimkina N.V.
doaj   +1 more source

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