Results 51 to 60 of about 551,407 (218)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Stable plithogenic cubic sets [PDF]

Journal of Fuzzy Extension and Applications
In this article, the ideas of a stable plithogenic cubic set, stable plithogenic element, evaluation Plithogenic Set (PS), and stable plithogenic degree for fuzzy, intuitionistic and Neutrosophic Sets (NSs) are introduced, and associated properties are ...
Priyadharshini Ponnukumar, Nirmala Francis Xavier, Ramkumar Jaganathan   +2 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Development and multi-institutional validation of a deep learning model for grading of vesicoureteral reflux on voiding cystourethrogram: a retrospective multicenter studyResearch in context

EClinicalMedicine
Summary: Background: Voiding cystourethrography (VCUG) is the gold standard for the diagnosis and grading of vesicoureteral reflux (VUR). However, VUR grading from voiding cystourethrograms is highly subjective with low reliability.
Zhanchi Li, Zelong Tan, Zheyuan Wang, Wenjuan Tang, Xiang Ren, Jinhua Fu, Guangbing Wang, Han Chu, Jiarong Chen, Yuhe Duan, Likai Zhuang, Min Wu   +11 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Grounded report generation for enhancing ophthalmic ultrasound interpretation using Vision-Language Segmentation models

npj Digital Medicine
Accurate interpretation of ophthalmic ultrasound is crucial for diagnosing eye conditions but remains time-consuming and requires significant expertise.
Kai Jin, Qixuan Sun, Daohuan Kang, Ziyao Luo, Tao Yu, Wenzheng Han, Yi Zhang, Meng Wang, Danli Shi, Andrzej Grzybowski   +9 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Automatic identification of anterior mediastinal lesions based on deep learning algorithm

Guangxi Yike Daxue xuebao
Objective To develop and verify a deep learning algorithm for the automatic detection of anterior mediastinal lesions, aiming to improve the diagnostic efficiency of such lesions in chest CT examinations.
Baolei LYU, Tian GUAN, Chao SUN, Jiayi GENG, Cancan CHEN, Dawei WANG, Xiuyuan CHEN   +6 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source