Results 81 to 90 of about 5,076,655 (301)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On the Internal Structure of Bacteriophage Lambda [PDF]

The Journal of General Physiology, 1966
The structure of bacteriophage lambda has been studied by electron microscopy of negatively stained particles. The phage particles will eject their DNA if they are heated or dialyzed against a chelating agent. The ghost particles, so formed, have a channel running down their tails.
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Commitment to Excellence in the New: Revival of the Notion of "the Fine” for Comprehension of the Dialogue between Artistic Image and Intellectual Idea in a Modern Architectural Form

Проект Байкал, 2016
The revival of the notion of "the fine" has become one of the tasks in the framework of matching historical and theoretical issues related to architectural criticism at the present stage of architectonic thinking integration into the space of a non ...
Yuri Volchok
doaj   +1 more source

Comprehensive study of old hummocks in the Arctic Ocean

Лëд и снег, 2020
In May 2015, the old hummock located to the North of the Bennett island (the East Siberian Sea) was investigated using several methods, among which were water thermal drilling, tachometric and sonar surveys, underwater video recording, as well as ...
R. B. Guzenko, Ye. U. Mironov, V. V. Kharitonov, S. V. Khotchenkov, R. I. May, V. S. Porubaev, S. М. Кovalеv, K. А. Kornishin, Ya. О. Efimov   +8 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Evaluation of Mixing Effect on Coupled Heat Release and Transfer Performance of a Novel Segregated Solid Rocket Motor

Aerospace
The effect of mixing on coupled heat release and transfer performance of a novel segregated solid motor is numerically evaluated with a transient two-dimensional combustion model.
Shuyuan Liu, Yu Zhang, Limin Wang, Zhengchun Chen, Songqi Hu   +4 more
doaj   +1 more source

Uji Validitas, Struktur Internal, dan Measurement Invariance pada Alat Ukur Achievement Goal Orientation

Jurnal Pengukuran Psikologi dan Pendidikan Indonesia, 2019
Achievement goal orientation (AGO) is the goal orientation to achieve achievement. This study aims to explore information about the achievement goal orientation (AGO) measurement tool.
Jamaludin Jamaludin
doaj   +1 more source

Accounting of the internal structure of the ice hummock keel in thermodynamic calculations of the evolution of the consolidated layer

Лëд и снег, 2020
Materials from long-term field observations of the internal structure of ice hummocks in the Arctic seas were analyzed. Empirical expressions describing the porosity distribution of the underwater part of a newly-formed hummock depending on the depth and
O. M. Andreev
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source