Results 111 to 120 of about 1,550,292 (307)

Steady but model dependent Arctic amplification of the forced temperature response in 21st century CMIP6 projections

Environmental Research: Climate
We examine sources of uncertainty in projections of Arctic amplification (AA) using the CMIP6 multi-model (MM) ensemble and single model initial-condition large ensembles of historical and future scenario simulations.
Stephanie Hay, James A Screen, Jennifer L Catto   +2 more
doaj   +1 more source

The Max Planck Institute Grand Ensemble: Enabling the Exploration of Climate System Variability

Journal of Advances in Modeling Earth Systems, 2019
The Max Planck Institute Grand Ensemble (MPI‐GE) is the largest ensemble of a single comprehensive climate model currently available, with 100 members for the historical simulations (1850–2005) and four forcing scenarios.
Nicola Maher, Sebastian Milinski, Laura Suarez‐Gutierrez, Michael Botzet, Mikhail Dobrynin, Luis Kornblueh, Jürgen Kröger, Yohei Takano, Rohit Ghosh, Christopher Hedemann, Chao Li, Hongmei Li, Elisa Manzini, Dirk Notz, Dian Putrasahan, Lena Boysen, Martin Claussen, Tatiana Ilyina, Dirk Olonscheck, Thomas Raddatz, Bjorn Stevens, Jochem Marotzke   +21 more
doaj   +1 more source

Greenhouse warming and internal variability increase extreme and central Pacific El Niño frequency since 1980. [PDF]

Nat Commun, 2023
Gan R, Liu Q, Huang G, Hu K, Li X.
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Ensemble bias correction of climate simulations: preserving internal variability. [PDF]

Sci Rep, 2021
Vaittinada Ayar P, Vrac M, Mailhot A.
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Prompt Optical Emission from Gamma-ray Bursts with Non-single Timescale Variability of Central Engine Activities

, 2013
The complete high-resolution lightcurves of Swift GRB 080319B present an opportunity for detailed temporal analysis of the prompt optical emission. With a two-component distribution of initial Lorentz factors, we simulate the dynamical process of the ...
Li, Zhuo, Xu, Si-Yao
core   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source